Stan is the father/husband of the Smith family. As the family's breadwinner, he works for the Central Intelligence Agency. Although he once held the position of a case officer at the CIA, he is now a weapons expert for the agency. Stan often makes the mistake of applying the same extreme measures suited and used for his job in his personal life and with his family. Stan is portrayed as drastic, endangering, rash, insensitive, inconsiderate, dog-eat-dog, and very masculine. Early on in the series, he was heavily emphasized as a conservative Republican

who is the wife of Stan Smith and mother to Hayley and Steve. She is portrayed as a stereotypical housewife who enjoys cleaning but also has a wild past and a rebellious, adventurous side, often getting into trouble with her family and the alien Roger. Her backstory includes being adopted by Chinese parents (the Lings) after being abandoned by her biological parents, and she has a history of promiscuity before marrying Stan.

who serves as the liberal, often hypocritical, older sister to Steve and daughter of Stan and Francine. She is known for her strong political convictions, which often clash with her conservative father, and her on-again, off-again relationship with her husband, Jeff Fischer.

known for his interests in science fiction, fantasy, and Dungeons & Dragons, and his strong friendship with the family's alien, Roger, often leading to surreal adventures. He is a social outcast at Pearl Bailey High School, frequently seen with his friends Snot, Toshi, and Barry, and often clashes with his hyper-masculine father, Stan, who wants him to be more athletic.

a sarcastic, hedonistic alien who lives with the Smith family and creates numerous personas, or Roger Rabbit, the animated rabbit from Who Framed Roger Rabbit?, a character from a novel and film who is a cartoon star. Other notable fictional Rogers include the sadistic boy from Lord of the Flies. Personality: Narcissistic, selfish, and cynical, often driven by his own desires, but occasionally shows a softer side.

Identity: A talking gold fish who is a member of the Smith family. Role: A supporting character, often overlooked by the family. Personality: Cynical and often treated poorly by the family, he is sometimes shown to care for Francine.