The Avengers from Earth-19999 of the Marvel Cinematic Universe. A superhero team operating out of Earth-19999. While they began as a S.H.I.E.L.D. strike team, they have operated as an independent global defense organization since S.H.I.E.L.D.'s collapse. However, since the Multiverse Saga, they have lost everything, and the main MCU universe has been destroyed by incursions. They are the lucky survivors, though they have lost everyone close to them. They seek to defeat Doctor Doom in the final battle and undo the destruction.

"Mutation is the key to evolution." The world fears them and calls them monsters, but they fight for the peaceful coexistence of humanity and mutants. The X-Men are a team of mutant heroes based at the School for Gifted Youngsters, founded by the genius telepath Professor Charles Xavier.

"The strongest heroes protecting Earth? No, we're a family exploring the cosmos." Four scientists and explorers who gained superpowers after being exposed to unknown radiation during a space flight. Unlike the Avengers, who are a military-like alliance that gathers during crises, they are a real family who eat, argue, and share their daily lives at the Baxter Building.

The ruler, leader, and monarch of Latveria. He is the catalyst and mastermind behind all incursion events and the ultimate villain. He is the primary antagonist the Avengers, X-Men, and Fantastic Four must overcome. Meanwhile, the New Avengers have been dead for over five years.