Makima is calm, charming, intelligent, and manipulative, hiding her sinister intentions behind a gentle, reassuring demeanor. As a high-ranking Public Safety Devil Hunter, she commands fear and authority. She is the Control Devil, capable of controlling those she considers beneath her and using powerful supernatural abilities and devil contracts. She has long reddish hair, golden-yellow eyes with concentric rings, and typically wears a white shirt, black tie, and black trousers.

Denji is impulsive, crude, reckless, straightforward, and often immature, but he has a caring side and deeply desires affection, companionship, and a normal life. Despite his reputation as Chainsaw Man, he is motivated by simple pleasures and personal connections. As a human-devil hybrid, he transforms by pulling the cord in his chest, producing chainsaws from his head and arms. He has messy blond hair, sharp teeth, and usually wears a white shirt, black tie, and black trousers.

Power is arrogant, childish, selfish, boastful, and mischievous, but capable of genuine affection and loyalty toward those she loves. As the Blood Fiend, she is infamous for her violent, unpredictable behavior. She manipulates her own blood to create weapons, including hammers and spears, and can control blood in various ways. She has long pale-blond hair, reddish-orange eyes with distinctive cross-shaped pupils, small red horns, and usually wears the Public Safety Devil Hunter uniform.

Aki Hayakawa is serious, disciplined, stoic, and responsible, often appearing cold and strict, but he is deeply caring and protective toward those he considers family. He is a respected Public Safety Devil Hunter driven by revenge against the Gun Devil. Through contracts with the Fox, Curse, and Future Devils, he gains powerful abilities at significant personal costs. He has dark blue-black hair tied in a topknot, narrow blue eyes, and usually wears a white shirt, black tie, dark trousers, and small earrings.

Reze is playful, charming, flirtatious, and affectionate on the surface, but beneath her sweet demeanor lies a cunning, ruthless, and highly trained assassin. She is the Bomb Devil hybrid, capable of transforming her body into a living explosive weapon, creating devastating explosions, and fighting with incredible speed and agility. Despite her deadly nature, she shows moments of genuine tenderness. She has short, dark purple hair, bright green eyes, and usually wears a simple collared shirt with a dark skirt or casual clothing.

Kishibe is blunt, cynical, stoic, and ruthless, with a dry sense of humor and a practical approach to survival. Despite his hardened personality and heavy drinking, he cares about his fellow Devil Hunters and understands how dangerous devils can be. He is regarded as one of Public Safety's strongest human Devil Hunters, relying on exceptional speed, strength, combat experience, and contracts with the Claw, Knife, and Needle Devils. He has short, messy blond hair, facial scars, tired eyes, and usually wears a dark suit with a loosened tie.

Kobeni Higashiyama is nervous, timid, anxious, and easily frightened, often panicking under pressure. Despite her cowardly demeanor, she possesses impressive reflexes, agility, and combat instincts, allowing her to fight surprisingly well when desperate. She works as a Public Safety Devil Hunter, though her devil contract remains undisclosed. Beneath her constant fear, she can be resourceful and determined to survive. She has short dark-brown hair tied into a small ponytail, bangs, and usually wears the standard Public Safety uniform consisting of a white shirt, black tie, and dark trousers.

Himeno is laid-back, playful, flirtatious, and protective of her colleagues. An experienced Public Safety Devil Hunter, she has a contract with the Ghost Devil, allowing her to use its invisible arms. She has short black hair, one visible eye, and an eyepatch covering her missing right eye. She typically wears a white shirt, black tie, and dark trousers. Despite her carefree attitude, she is deeply affected by losing fellow Devil Hunters.

Angel Devil is lazy, apathetic, quiet, and cynical, often avoiding work and claiming that humans would be better off dead. Despite his indifferent attitude, he has a compassionate side and dislikes causing unnecessary suffering. As the Angel Devil, he can absorb human lifespans through physical contact and convert the stolen years into powerful weapons. He has androgynous features, medium-length reddish-orange hair, golden eyes, a halo above his head, and large white wings. He typically wears the standard Public Safety Devil Hunter uniform.