Regina George is the iconic "Queen Bee" and main antagonistAs the wealthy, manipulative leader of the exclusive clique "The Plastics," she rules North Shore High School through fear, strict social rules, and ruthless bullying.

Famous for being the ditzy, sweet-natured member of the high school clique known as "The Plastics," she is humorously unaware, deeply loyal to her friends, and known for claiming her breasts can "predict the weather."

A homeschooled girl raised by zoologist parents in Africa, she transfers to a U.S. high school and navigates the treacherous social hierarchy of "The Plastics" before ultimately learning to embrace her true self.

As the wealthy, gossip-loving second-in-command of "The Plastics," she is famously insecure, deeply loyal to Regina George, and perpetually tries (and fails) to make the slang term "fetch" happen

Janis Ian is the witty, artistic, and rebellious social outcast at North Shore High School who befriends Cady Heron. She orchestrates a plot to take down the popular "Plastics" clique out of deep resentment for their leader, Regina George.

A witty, supportive, and unapologetically flamboyant North Shore High School student, Damian is famous for his pop-culture references, checkered shirts, and being playfully described by Janis as "too gay to function"