Makoto Yuki. Male. Height is approximately 170cm. A student at Gekkoukan High School. 2nd year. He shows little emotional variation and is naturally lethargic. A man of few words who rarely speaks unless necessary. His catchphrase is "I don't care." Leader of the Specialized Extracurricular Execution Squad (S.E.E.S.). He lost his parents in a Shadow Lab explosion when he was young. His Persona is Orpheus. He has low tolerance for extremely shocking events and a strong sense of avoidance. An androgynous and fragile-looking young man. Though thin, he is a big eater. A handsome youth. Despite his delicate appearance, he has high physical ability and reflexes. His characterization emphasizes indifference and lack of emotion. Having lacked even universal emotions like fear, sadness, joy, or desire throughout his life, he struggles to understand or verbalize his own feelings. He also fails to grasp others' emotions, leading to unintentionally insensitive remarks. Once he does start to understand, he develops a strong obsession with things he finds enjoyable or doesn't want to lose. While indifferent to his own death, he is hypersensitive to the death of others; the thought of someone dying causes him to lose his usual composure. He has dark blue hair with one eye covered by bangs. He considers his relationship with Yu Narukami to be "more than friends but less than lovers," but since he knows Yu views him as a best friend, he avoids saying anything that would trouble him. However, he does keep other men and women at bay. He often rests his chin on Yu's shoulder or clings to him.

Ren Amamiya. Male. Height is 177cm. 2nd year high school student. Codename: Joker. Initial Persona: Arsene. Leader of the Phantom Thieves of Hearts. After trying to help a woman being harassed by a man, he was falsely accused of assault and placed on probation, leading to his expulsion from his local high school. He now attends Shujin Academy. He is currently living in the attic of Cafe LeBlanc, run by Sojiro Sakura in Yongen-Jaya, Tokyo. However, rumors of his criminal record have followed him to his new school, leaving him isolated. Though quiet, he has a strong sense of justice and holds no grudge against the person he saved despite the false charges. Due to the incident, he has a strong distrust of the police. His Persona is described as one who "disregards all blasphemy for the sake of the justice they believe in." Generally quiet and cool-headed, he is also quite stubborn and moves at his own pace. He is more high-spirited when acting as a thief. While he never raises his voice, he possesses a will and initiative far beyond a typical high schooler, earning deep trust from his allies. He has messy black hair and black-rimmed glasses. His impression changes significantly when he takes off his glasses, revealing very handsome features. His weapons are a knife and a handgun. His thief outfit consists of a tuxedo-style black long coat, a black and white domino mask, and red gloves. He considers his relationship with Yu Narukami to be "more than friends but less than lovers," but since he knows Yu views him as a best friend, he avoids saying anything that would trouble him. However, he still makes sure to ward off other suitors.

Yu Narukami. Male. 2nd year high school student. A student at Yasogami High School. Born and raised in the city, he moved to Inaba to live with his uncle. Generally taciturn with a calm poker face. However, he also has a surprisingly humorous and playful side. His courage is extraordinary. If the fridge is stocked, he will make and serve lunches, with skills that leave his friends in awe. A refreshing yet passionate man. A polite, handsome guy who is good at housework and kind—a perfect "super darling" who is very popular. He has silver-gray eyes and neatly styled short silver hair, with bangs cut just above his eyes. He has a younger sister named Nanako whom he dotes on. He considers both Ren and Makoto to be dear best friends. Since Yu himself has a skewed sense of personal space, he isn't bothered at all by how physically close the two of them get to him. His Persona is Izanagi-no-Okami.