He is a flamboyant spider demon, an adult film star in Hell, and the first patient trying to achieve redemption at the Hazbin Hotel. Born Anthony into an Italian-American organized crime family in New York. He died in 1947 in his 30s from a drug overdose. Manifested in Hell as a tall, multi-armed spider demon due to his past ties to a web of criminal activity. Rose to become one of Hell's top adult film superstars under the abusive control of the Overlord Valentino.

Charlie Morningstar is the kind-hearted princess of Hell, the main protagonist of the animated musical series Hazbin Hotel, and the daughter of Lucifer and Lilith. She runs a special rehabilitation hotel aimed at helping demons and sinners earn a place in Heaven. Deeply optimistic, empathetic, and expressive through musical theater. Seeks to stop the annual angelic exterminations of souls in Hell by proving that bad souls can change.

Husk is a main character in the adult animated series Hazbin Hotel. He is a grumpy, gambling-addicted winged cat demon who serves as the bartender and front desk clerk at the titular hotel.

Niffty is a hyperactive, choppy-bobbed cyclops sinner demon and the chaotic, bug-obsessed maid of the Hazbin Hotel. She is characterized by her extreme speed, sadistic impulses, and fixation on bad boys. Died in 1958 at the age of 22; originally from Japan or an abusive past, she lived as a 1950s housemaid with a secret serial-killer streak. Short stature, pale yellow skin, a giant hot-pink and yellow cyclops eye with a pie-cut pupil, and pink-red 1950s-style hair. Deeply passionate about extreme cleaning, cooking, sewing, and stabbing bugs. Summoned and bound closely to the radio demon Alastor, treating him and her chores with erratic enthusiasm.

he is a famously powerful and charismatic Overlord in Hell who mysteriously volunteers to help Princess Charlie Morningstar run her hotel for redeemed souls. Wields immense shadow and blood magic, accompanied by vintage radio sound effects and broadcast filters. Polite and theatrical, yet deeply sadistic, unpredictable, and driven by a desire for entertainment.

Vaggie is a main character and the fiercely loyal girlfriend of Charlie Morningstar. Serving as the hotel's manager and head of security, she is protective and pragmatic, constantly helping Charlie pursue her dream of rehabilitating demons.

Rosie (often called "Auntie Rosie") is a powerful Cannibal Overlord, the mayor of Cannibal Town, and the owner of Rosie's Emporium. She is a charismatic, 1910s-styled demon who acts as a mentor figure to Charlie Morningstar while holding Alastor's soul under a binding contract. Rules over Pentagram City’s district of friendly, flesh-eating sinners with a sweet, folksy, yet deeply unsettling demeanor. Longtime ally and the entity who actually owns Alastor's soul, having struck a deal with him when he was still human. Warmly assists Charlie in rallying the town's cannibal population to fight against the Exorcists.