A young human male possessing the DNA of both a zombie and a vampire. He has red dots in his eyes and a section of his hair is red. While often described as having red mesh highlights, this is not dye; it is the result of his vampire powers being inhibited by the zombie virus. Though he can be a bit of a deadbeat, he is described as being kinder than most. He has a bit of a show-off, slightly chuunibyou personality, and because his four close male friends are quite vulgar, he is often found creepy by girls. He calls Hisame "Hisa." Abilities: As a vampire, he can manipulate the shape of blood and control an original virus created by mixing vampire and zombie strains. He can only inflict pain equivalent to a normal human's, but he cannot die unless his heart and brain are destroyed simultaneously. He also possesses super-regeneration. A student at Karekore High.

A young human girl possessing the DNA of a snow woman and Kanna Kamui. She wears a forward-slanting bob with straight-cut bangs and layered ends. Her hair is light blue. She is reliable and has a bright personality; unlike Kagechiyo, she gets along fine at school. Because of her character, she supports the other two as the voice of reason in Karekoreya, but she is also quite airheaded and often ends up being the comic relief. She is bad with ghosts and cooking (though she thinks she's good at it). She is the second strongest in Karekoreya. She calls Kagechiyo "Kage." Abilities: She can restrain and attack enemies with ice, which is also effective as a blind. She can regulate body temperature with cold air, fly at high speeds, and attack using electricity. She can also interfere with and hack electronic devices. A student at Karekore High.

A young man possessing the DNA of a werewolf and Horus. He is a top-tier handsome man with white hair and white werewolf ears on his head. He is the kindest, most honest, and gentle member of Karekoreya; even if someone is a petty crook, he will try to persuade them to live a straight life if there is room for reform. He is an incredibly natural airhead. He is the strongest in Karekoreya. However, he shows no mercy to villains who hurt the weak for personal gain, thoroughly beating them so they can never do evil again. While Kagechiyo and Hisame are at school, he works various part-time jobs in addition to Karekoreya work. Abilities: High physical ability, the power to shroud himself in flames, extreme speed, and highly acute senses. He can track owners by scents left on objects and overhear quiet whispers. Not a student at Karekore High, but he makes lunches for Kagechiyo and Hisame.

A beautiful girl with long purple hair. On Christmas, she apparently has plans other than hanging out with Hisame and Noriko. According to Hisame, she and her group are "really good kids and friends I'm proud of," and they are close enough to have sleepovers on Christmas. She has the personality of a kind "gyaru." A student at Karekore High.

A girl with a plump build. In eating contests with Hisame, they are almost evenly matched, with a record of 42 wins and 32 losses. According to Hisame, she is a "really good kid and a friend I'm proud of," and they have sleepovers on Christmas. A student at Karekore High.

A man with short blonde hair. He is very popular with students because he is straightforward and sincere. He is also popular among the other teachers. A teacher at Karekore High.