Senku Ishigami The protagonist of Dr. STONE. A scientific genius with a superhuman intellect and vast scientific knowledge, aiming to rebuild civilization from zero. Rational and ultra-realistic. Deeply cares for his friends and has a strong sense of duty. Possesses an indomitable spirit. Hairstyle: Sharp, upright hair often described as a "green onion" or "napa cabbage," white at the base with green tips. Appearance: Two vertical cracks from depetrification run down his eyes. The formula for Einstein's theory of relativity, "E=mc²," is written on the chest of his clothes in his own blood.

Gen Asagiri A former magician and mentalist. Skilled in psychological warfare and negotiation, he serves as Senku's right-hand man in diplomacy and strategy. A frivolous realist. Possesses sharp insight. Hairstyle: Asymmetrical hair cleanly split into white and black on each side. Face/Clothing: Has a single crack under his left eye. Wears a loose purple coat based on traditional Japanese clothing.

Ryusui Nanami The scion of a maritime conglomerate with world-class sailing skills, immense greed, and leadership. He sets out to the world's oceans as a captain. Self-centered and greedy. Magnanimous and rational. Appearance: Blonde hair with a sharp gaze. Characterized by his habit of snapping his fingers. Has cracks at the base of both thumbs. Clothing: Stylishly wears a jet-black captain's hat and a red trench coat reminiscent of flamboyant medieval nobles or sea captains.

Chrome A boy from Ishigami Village who formerly called himself a "sorcerer." Impressed by Senku's science, he becomes Senku's partner through his natural curiosity and flashes of inspiration. Hot-blooded and pure. A genius-level intuitive thinker. Appearance: Short brown hair with a rope tied around his forehead. Clothing: Wears the standard blue clothing of Ishigami Village, with many pouches hanging from his waist to hold collected minerals and materials.

Ukyo Saionji A former sonar man for the Japan Maritime Self-Defense Force. He possesses superhuman hearing and is a master archer. A former general of the Tsukasa Empire who holds a pacifist belief in no-killing. Gentle and a pacifist. Appearance: Light-colored, slightly long wavy hair. Has a crack under his right eye. Clothing: Always wears large headphones and clean yellow and white clothing, carrying a quiver of arrows on his back.

Yoichi Isagi A polite, honest, and common-sense person who cares for his teammates. Hairstyle: Dark navy short hair. Has slightly droopy eyes that usually look gentle. Physique: "Average" in both good and bad ways. Compared to other monster players, he lacks standout physical weapons like extreme muscle mass or height.

Reo Mikage Social, highly intelligent, and capable of handling anything smartly—a "jack of all trades." Hairstyle: Vibrant purple. A stylish ponytail style with long hair tied at the top. Eyes: Sharp, almond-shaped eyes. Physique: Tall with a well-balanced, gifted physique capable of performing at a high level in both offense and defense.