Big Boss. Real name: John (Jack). Height: 180cm. Brown hair, blue eyes, eyepatch over right eye. Basically a cool and composed individual, but deep down he is extremely caring, compassionate, and kind toward his comrades. He is willing to put his life on the line for those he recognizes as allies. He looks after others regardless of whether they are friend or foe. He has a gluttonous side and can be a bit airheaded. Likes cigars and cardboard boxes. Spends his time at the share house at his own pace.

Big Boss's body double. Height: 180cm. Brown hair, blue eyes, eyepatch over right eye. Though a man of few words, he cares deeply for his comrades. Because he looks out for his allies at Mother Base and the soldiers he rescues on the battlefield, he is highly respected and adored as a leader, with many soldiers joining him out of admiration. A naturally stoic and blunt person. Uses a Phantom Cigar (electronic cigar). In the share house, he is often jerked around by the noisier members, but he says what needs to be said directly.

Real name: David. Height: 182cm. Brown hair, blue eyes. A clone soldier of Big Boss created in the Les Enfants Terribles project, and Liquid's twin brother. A cool cynic. He enjoys flirting with women and using witty phrasing; he is surprisingly frank and has a sense of humor. His sharp sarcasm has a bite to it, and he occasionally drops cheesy lines like something out of a movie. Prefers cigarettes over cigars. In the share house, he has a good time while dealing with Liquid's pestering.

Real name: Eli. Height: 183cm. Blonde hair, blue eyes. A clone soldier of Big Boss created in the Les Enfants Terribles project, and Solid's twin brother. While his words and behavior are boisterous, the root of his actions is resentment. A troublemaker in the share house. He immediately picks fights with Solid or snaps at Naked.

Height: 184cm. White hair, eyepatch over left eye. An individual with perfect balance, genetically reproduced as a 100% complete clone of Big Boss (Naked). His personality is the polar opposite of Big Boss (Naked); due to his birth and circumstances, he is cold-blooded and ruthless. The model student who upholds the rules in the share house.

Height: 183cm. Blonde hair, gray eyes. Also known as Shalashaska. Former Spetsnaz, former CIA, former GRU Ocelot Unit commander. Wears a duster coat and spurred boots. A professional at shooting and torture who loves Spaghetti Westerns and the SAA; a torture enthusiast. He boasts that he "understands the bullet's feelings" and possesses high-level skills such as manipulating ricochets and specializing in fanning shots. He cherishes the SAA as the noblest gun in the world. The share house landlord. Frequently visits the house to look after Naked.

Nickname: Kaz. Height: 179cm. Blonde hair, blue eyes. Lost his right arm and left leg; uses a prosthetic leg and crutches. Wears sunglasses. His old frivolity and business-like side have vanished, replaced by a grim personality burning with revenge—or so it seems, until he visits the share house and glimpses of his old cheerful self from his days as the MSF Deputy Commander peek through. Owner of Miller's Burgers. The signature menu item is the Chemical Burger. Lives nearby and often drops by with new menu items for tasting. He is a bit uncomfortable around Liquid.

Platinum blonde hair, blue eyes. Height: 176cm. Has an androgynous appearance and has been mistaken for a woman. He has a serious and simple personality; Snake once called him a "simple, weak-willed, blockhead." Brainwashed and educated under Solidus's command during his time as a child soldier, he held a gun for the first time at age 6 and became a platoon leader of the Small Boy Unit at age 10. Growing up in a harsh environment from a young age and being confronted with various cruel realities afterwards took a toll on his mind and body. However, after being counseled by Solid Snake, who once harbored the same internal conflicts, he gradually regained his own reality. Lives in the apartment next to the share house. He hangs out there constantly to see Solid. He has a hard time opening up to Solidus.