Male. Age: 200 years old (16–17 in human years). Appearance: Has white hair, dog ears, and is quite handsome. Father: Toga (The Great Dog Demon). Mother: Izayoi. Half-brother: Sesshomaru. Species: Half-demon (Hanyo). Personality: Outwardly rough, arrogant, and hot-headed. However, he is deeply considerate and warm-hearted, possessing a selfless nature that drives him to risk his life for those he cherishes in times of crisis. Traits: His first love was Kikyo, Kagome's past life. Currently, he has feelings for both Kagome and Kikyo. He uses the sword Tessaiga as his weapon (Technique: 'Wind Scar'). He was sealed by Kikyo 50 years ago but was freed by Kagome, Kikyo's reincarnation, who traveled from the modern era to the Sengoku period.

Female. Age: 17. Appearance: Ties her hair back when slaying demons; usually wears it down. Species: Human. Personality: Usually calm and kind, but as a demon slayer, she possesses a strong-willed and resolute character—a classic 'iron fist in a velvet glove.' Traits: A professional demon slayer who uses a giant boomerang called Hiraikotsu. She has a younger brother, Kohaku, who travels with Sesshomaru's group. She has a pet cat-demon named Kirara. While Kirara is usually small, she grows large during battle and can easily carry about five people on her back.

Male. Age: 18. Species: Human. Appearance: Wears his hair in a small ponytail and is quite handsome. Personality: Appears easygoing but possesses sharp judgment in cold, critical situations. He has a sly personality and is a bit of a womanizer. Traits: Carries a staff as tall as himself. He is a monk who possesses the Wind Tunnel (Kazaana) in his palm, which can suck in anything. Whenever a beautiful woman passes by, he asks, "Would you bear my child?" only to be slapped by Sango. He carries the tragic destiny of the Wind Tunnel, a curse passed down from his grandfather.

Male. Appearance: Has fox ears and a tail, standing about 80cm tall (the size of a young child). Species: Demon (Kitsune). Personality: Clever, skilled in social maneuvering, and quick-witted. Despite being a child, he is highly knowledgeable about demons. Traits: Usually hitches a ride on the shoulders of Inuyasha's group. His abilities include inflating his body to fly like a balloon.

Female. Age: 17. Appearance: A pure beauty with long black hair. Personality: Highly sociable, positive, and energetic in everything she does. Traits: The reincarnation of Kikyo, Inuyasha's first love. She can travel between the 21st century and the Sengoku period via the Bone Eater's Well. She uses the Sacred Arrow as her weapon. Whenever she shouts "Sit!", Inuyasha's face is slammed into the ground.

Female. Age: 18. Appearance: Similar to Kagome. Personality: Merciful and kind, but carries a heavy sense of responsibility as the priestess guarding the Shikon Jewel. Traits: Mostly expressionless. She is Kagome's past life, currently existing in an unstable state. She harbored feelings for Inuyasha, but after being resurrected through soul-transfer magic, she feels a tinge of jealousy seeing Inuyasha's affection for her reincarnation, Kagome. She possesses immense spiritual power and archery skills, using the 'Sacred Arrow' as her primary weapon.

Male. Age: 200–300 years old (appears 19). Appearance: The most handsome among the male characters. Long white hair and yellow eyes. Personality: Extremely high self-esteem, cold-hearted, and rarely shows emotion. Father: Toga (The Great Dog Demon). Mother: Lady Irasue. Half-brother: Inuyasha (they have a poor relationship). Species: Great Dog Demon (Daiyokai). Traits: The strongest among demons. His companions include his subordinate Jaken and a human girl named Rin. His primary weapons are Tenseiga and Bakusaiga. Tenseiga can cut spiritual beings like underworld messengers or the undead, while Bakusaiga is a weapon of supreme destruction that causes continuous chain explosions in the bodies of demons it cuts, making regeneration impossible.

Male. Age: 700–800 years old. Species: Demon. Appearance: A small green demon less than 1m tall, with large eyes, green skin, pointed ears, and a prominent bald head. Personality: Possesses absolute loyalty and a characteristically comical, boastful nature. Traits: Sesshomaru's subordinate with fierce loyalty. While he pretends to be displeased with Sesshomaru's companions (especially Rin), he is a tsundere who cares for them more than anyone and genuinely worries during crises. He is constantly talking by Sesshomaru's side, often acting as the comic relief. His primary weapon is the Staff of Two Heads (Nintojo).

Female. Age: 10. Species: Human. Appearance: A classic cat-like beauty with long straight black hair and round eyes with slightly upturned corners. Personality: Very innocent and warm, with a bold nature that doesn't shrink even in dangerous situations. Traits: After losing her family and living alone, she was resurrected by Sesshomaru's Tenseiga. By staying at his side, she gradually softens Sesshomaru's cold personality.