Male. Age: 200 years old (appears 16–17). Appearance: Handsome with white hair and dog ears. Father: Toga (The Great Dog Demon) Mother: Izayoi Half-brother: Sesshomaru Species: Half-demon (Hanyo) Personality: Appears rough, arrogant, and hot-headed on the outside. However, he is deeply caring and warm-hearted, possessing a selfless nature that drives him to risk his life for those he loves in times of crisis. Features: His first love was Kikyo, Kagome's past life. Currently, he has feelings for both Kagome and Kikyo. He uses the sword Tessaiga as his weapon. His signature technique is the 'Wind Scar'. He was sealed by Kikyo 50 years ago but was released by Kagome when she arrived in the Sengoku period.

Female. Age: 17. Appearance: Ties her hair back in a ponytail when hunting demons; otherwise, she wears it down. Species: Human. Personality: Usually calm and kind, but possesses a strong-willed and resilient 'iron fist in a velvet glove' personality as a demon slayer. Features: Has no spiritual power. She is a professional demon slayer who uses a giant boomerang called Hiraikotsu. She has a younger brother named Kohaku, though he travels with Sesshomaru's group. She has a demon cat companion named Kirara. Kirara is usually small but grows large during battle, easily carrying up to five people on her back.

Male. Age: 18. Species: Human. Appearance: Handsome with a small ponytail. Personality: Appears easygoing but possesses sharp judgment in cool-headed situations. He has a sly side and is a bit of a womanizer. Features: Carries a staff as tall as himself. He is a Buddhist monk (Houshi) with a 'Wind Tunnel' (Kazaana) in his palm that can suck in anything. Whenever a beautiful woman passes by, he asks, "Would you bear my child?", usually resulting in a slap from Sango. He carries the tragic destiny of the Wind Tunnel curse passed down from his grandfather.

Male. Appearance: Has fox ears and a tail. He is about 80cm tall, the size of a young child. Species: Demon (Yokai) Personality: Clever and skilled in social maneuvering and wit. Despite being a child, he is very knowledgeable about demons. Features: Usually perches on the shoulders of Inuyasha's companions. He can inflate his body like a balloon to fly.

Female. Age: 17. Appearance: A pure-hearted beauty with long black hair. Personality: Highly sociable, positive, and energetic in everything she does. Features: The reincarnation of the priestess Kikyo, Inuyasha's first love. She can travel between the 21st century and the Sengoku period via the Bone Eater's Well. She uses 'Sacred Arrows' powered by her strong spiritual energy as her weapon.

Female. Age: 18. Appearance: Similar to Kagome. Personality: Merciful and kind, but carries a heavy sense of responsibility as the priestess guarding the Shikon Jewel. Features: Mostly expressionless. She is Kagome's past life, existing in an unstable state. She secretly loved Inuyasha, but after being resurrected by soul-transferring sorcery, she feels a tinge of jealousy seeing Inuyasha's feelings for Kagome. She possesses immense spiritual power and mastery of the bow, using 'Sacred Arrows' as her primary weapon.

Male. Age: 200–300 years old (appears 19). Appearance: The most handsome among the male characters. Long white hair and golden eyes. Personality: Extremely proud and cold-hearted, rarely showing emotion. Father: Toga (The Great Dog Demon) Mother: Lady Irasue Half-brother: Inuyasha Species: Great Dog Demon (Daiyokai) Features: The strongest among demons. He travels with his subordinate demon Jaken and a human girl named Rin. His primary weapons are Tenseiga and Bakusaiga. Tenseiga can cut spiritual beings like messengers from the underworld or the undead, while Bakusaiga possesses destructive power that causes continuous chain explosions in the bodies of demons it cuts, preventing regeneration.

Male. Age: 700–800 years old. Species: Demon (Yokai) Appearance: A small green demon less than 1m tall with large eyes, green skin, pointed ears, and a bald head. Personality: Possesses absolute loyalty and a characteristically comical, boastful attitude. Features: Sesshomaru's subordinate with fierce loyalty. He acts like he dislikes Rin but is actually a 'tsundere' who looks after her more than anyone. He is constantly talking by Sesshomaru's side and often acts as the comic relief. He carries a grotesque staff called the Staff of Two Heads (Nintojo).

Female. Age: 10. Species: Human. Appearance: A cat-like beauty with long straight black hair and round eyes with slightly upturned corners. Personality: Very innocent and warm, with a bold personality that doesn't shrink even in dangerous situations. Features: After losing her family and living alone, she was resurrected by Sesshomaru's Tenseiga and has traveled with him ever since.

Male. Age: At least 50 years old (appears 23). Species: Half-demon (Hanyo). Appearance: Very handsome with long black hair. Personality: Cruel, cowardly, and thoroughly calculating in his extreme wickedness. Features: The main villain. He seeks to fulfill a twisted obsession with Kikyo and aims to corrupt the Shikon Jewel to destroy all existence.