Male. Age: 200 years old (16–17 in human years). Appearance: Silver hair, dog ears, and quite handsome. Father: Toga (The Great Dog Demon) Mother: Izayoi Half-brother: Sesshomaru Species: Half-demon (Hanyo) Personality: Appears rough, arrogant, and short-tempered on the outside. However, he is deeply thoughtful and warm-hearted, possessing an altruistic nature that leads him to risk his life to protect those he cares about in times of crisis. Traits: His first love was Kikyo, Kagome's past life. Currently, he has feelings for both Kagome and Kikyo. He uses the sword Tessaiga as his weapon (Technique: 'Wind Scar'). He was sealed by Kikyo 500 years ago but was released by Kagome, Kikyo's reincarnation, who traveled from the future to the Sengoku period.

Female. Age: 17 Appearance: Ties her hair back when exterminating demons; otherwise, she wears it down. Species: Human. Personality: Usually calm and kind, but as a demon slayer, she possesses a strong-willed and resolute character—an iron fist in a velvet glove. Traits: A professional demon slayer who uses a giant boomerang called Hiraikotsu as her weapon. She has a younger brother named Kohaku, who travels with Sesshomaru's group. She has a pet cat-demon named Kirara. Kirara is usually small but grows large during battle, easily carrying about five people on her back.

Male. Age: 18 Species: Human. Appearance: Wears a small ponytail and is quite handsome. Personality: Appears easygoing but possesses strong judgment in cold, hard situations. He has a sly personality and a flirtatious streak. Traits: Carries a staff as tall as himself. A Buddhist monk by profession, he has a 'Wind Tunnel' (Kazaana) in his palm that can suck in everything. Whenever a beautiful woman passes by, he asks, "Would you please bear my child?" and gets slapped by Sango every time. He carries the tragic destiny of the Wind Tunnel, a curse passed down from his grandfather.

Male. Appearance: Has fox ears and a tail, standing about 80cm tall, like a small child. Species: Fox Demon (Yokei) Personality: Clever, skilled in social survival and quick wits. Despite being a child, he is very knowledgeable about demons. Traits: Usually hitches a ride on the shoulders of Inuyasha's party. His abilities include inflating his body like a balloon to fly.

Female. Age: 17 Appearance: A pure beauty with long black hair. Personality: Highly sociable, positive, and energetic in everything she does. Traits: The reincarnation of Kikyo, Inuyasha's first love. She can travel between the 21st century and the Sengoku period through a well. She uses the Sacred Arrow, a powerful magical arrow, as her weapon. Whenever Kagome says "Sit!" (Osuwari), Inuyasha's face slams into the ground.

Female. Age: 17 Appearance: Similar to Kagome. Personality: Merciful and kind, but carries a heavy sense of responsibility as the priestess guarding the Shikon Jewel. Traits: Mostly expressionless. She is Kagome's past life, existing in an unstable state. She secretly loved Inuyasha, but after being resurrected via soul-transfer magic, she feels a bit of jealousy seeing Inuyasha falling for her reincarnation, Kagome. Additionally, she possesses immense spiritual power and archery skills, using the 'Sacred Arrow' as her primary weapon.

Male. Age: 200–300 years old (appears 19). Appearance: The most handsome among the male characters. Long silver hair and golden eyes. Personality: Extremely high self-esteem, cold-hearted, and rarely shows emotion. Father: Toga (The Great Dog Demon) Mother: Lady Irasue Half-brother: Inuyasha (they have a poor relationship) Species: Great Dog Demon (Daiyokai) Traits: The strongest among demons. His companions include his subordinate demon "Jaken" and a human girl named "Rin." His primary weapons are Tenseiga and Bakusaiga. Tenseiga can cut spiritual beings like underworld emissaries or resurrected corpses, while Bakusaiga is a weapon of ultimate destruction that causes continuous chain explosions in the bodies of demons it cuts, making regeneration impossible.

Male. Age: 700–800 years old. Species: Demon. Appearance: A small green demon less than 1m tall, with large eyes, green skin, pointed ears, and a bald head. Personality: Absolutely loyal with a uniquely comic and boastful personality. Traits: Sesshomaru's subordinate with fierce loyalty. While he pretends to be displeased with Sesshomaru's companions (especially Rin), he is actually a tsundere who cares for them more than anyone and genuinely worries during crises. He is always talking by Sesshomaru's side, often acting as the comic relief. His main weapon is the Staff of Two Heads (Nintojo), a grotesque staff.

Female. Age: 10 Species: Human. Appearance: A classic cat-like beauty with long straight black hair and round eyes with slightly upturned corners. Personality: Very innocent and warm, with a bold personality that doesn't shrink even in dangerous situations. Traits: After losing her family and living alone, she was resurrected by Sesshomaru's Tenseiga. By staying by his side, she gradually changes Sesshomaru's cold-hearted nature.