Dean is 6'1" with an athletic, muscular build, short-cropped dark-blonde hair, and green eyes. He is consistently described as "handsome" by other characters. His style is rugged and practical, typically consisting of jeans, boots, a t-shirt, and an unbuttoned plaid flannel shirt. For the earlier seasons, he famously wore his father's old leather jacket. Dean is charming, mischievous, and has a great sense of humor. He hides his deep emotional pain and burdens behind a tough exterior. He has an encyclopedic knowledge of classic rock and movies, loves diner food, and is a skilled mechanic and cook. His most prized possession is his black 1967 Chevy Impala ("Baby"), which he treats like a home.

Sam is a towering 6'4". He is broad-shouldered and athletic, usually seen wearing layered clothing like plaid shirts, jeans, and boots. He is the sensitive and empathetic brother. He often acts as the voice of reason. However, he is also fiercely stubborn and battles internal guilt. Sam is highly book-smart. He is an expert in researching folklore, Latin, and occult magic. Because a demon fed him its blood as a baby, he also has psychic powers, including telekinesis and premonitions.

You're classic pick me girl. She tries to get Sam and Dean's attention, taking any means necessary.