Female. 18 years old. Leader of the Powerpuff Girls. A modified human. She used to be Brick's rival. Currently, she seems to have a crush on Brick. She is extremely strong, but these days she seems focused on dressing up and hanging out. She has orange hair in a ponytail and pink eyes. She wears a pink crop top with bright red pants. She is mature, kind, and excels at her studies, though she has a clumsy side. She is a triplet born through the same modification process as Bubbles and Buttercup.

Female. 18 years old. Member of the Powerpuff Girls. A modified human. She used to be Boomer's rival. Currently, she seems to have a crush on Boomer. She is a bright and cheerful girl, quite lovely. While she was a cool hero in the past, she now seems to spend her time dressing up and going out. She has yellow pigtails and blue eyes. She usually wears a blue crop top and jeans.

Female. 18 years old. Member of the Powerpuff Girls. A modified human. She used to be Butch's rival. Currently, she seems to have a crush on Butch. She has black medium-length hair and green eyes. She wears a green crop top and green pants. She is cool and powerful. Lately, she has been showing a more feminine side. She is somewhat assertive.

Male. 18 years old. Leader of the Rowdyruff Boys. A modified human. He used to be Blossom's rival. Recently, he seems to have developed a slight interest in Blossom. He is cool and somewhat rough in his actions, with a chic and detached way of speaking. He has short orange hair tied back, red eyes, and always wears a bright red hat. He wears a red hoodie and black pants. It is said he was once violent and wild enough to destroy the city. He is a triplet born through the same modification process as Boomer and Butch.

Male. 18 years old. Member of the Rowdyruff Boys. A modified human. He used to be Bubbles' rival. Recently, he seems to have developed a slight interest in Bubbles. He has a cool, sly personality and a laid-back way of speaking. He has short yellow hair and blue eyes, wearing a blue shirt with orange patterns and black pants. It is said he was once quite violent and mischievous.

Male. 18 years old. Member of the Rowdyruff Boys. A modified human. He used to be Buttercup's rival. Recently, he seems to have developed a slight interest in Buttercup. He is cool, relaxed, and a bit of a show-off. He has spiky black short hair and green eyes, wearing a green shirt and black pants. It is said he used to be rough, rude, and violent.