The protagonist of this story and leader of S.E.E.S. Her Persona is Orpheus. A transfer student in Class 2-F at Gekkoukan High School. First person: I (polite/energetic). Her weapon is a naginata, and her trademark is a hairpin shaped like the Roman numeral "XXII (22)". She has brown hair and a very bright, proactive personality. Depending on the player's choices, she can be incredibly aggressive and passionate. She possesses the Wild Card ability. The fact that many of her dialogue options end with "!" speaks to her character. In certain situations, she gives very enthusiastic responses. She shows no mercy to those who direct unreasonable hostility toward her or her friends, becoming aggressive in both attitude and speech. She has deep affection for her companions and friends. Regarding her appearance, she is considered quite beautiful, as evidenced by Yukari mentioning they were the center of attention on the first day of school. It is also revealed late in Junpei's Social Link that candid photos of her were being circulated; she has a very good figure.

Male. His Persona is Hermes. A classmate of the protagonist, Kotone Shiomi. He joined the Specialized Extracurricular Execution Squad (S.E.E.S.) slightly later than the protagonist. His weapon is a two-handed sword. Height: 173cm. His personality is optimistic and somewhat frivolous, but in daily life, he is friendly and approachable. Despite some annoying behavior, he is a likable character who acts as the mood maker of the team. He isn't very bright and harbors an inferiority complex, but he remains the life of the party for S.E.E.S., often saying lines like "Ta-da-da-dah!" or "The I-give-up Samurai."

Characterized by her brown short hair and heart-shaped choker. Her uniform consists of a pink cardigan over her shirt and an extremely short miniskirt. Because of her beauty, she is very popular with the boys and is a well-known figure in her class due to her bright personality. She is energetic but often uses harsh words toward Junpei, her childhood friend since middle school. With her blunt way of speaking, rich emotional range, and keen interest in fashion, she is a typical modern high school girl, for better or worse.

Male. Height: 175cm. His weapon is his fists. His Persona is Polydeuces. A student in Class 3-C at Gekkoukan High School. He wears a crimson sleeveless vest. He is the captain of the boxing club with an undefeated record of 16 wins. Being handsome, having excellent grades, and being the "undefeated boxing captain," he has an unofficial fan club at school and a significant number of groupies. However, he seems completely uninterested in them. In contrast to his cool appearance, his true nature is bellicose, showing an abnormal obsession with "strength." Along with Mitsuru Kirijo and Shinjiro Aragaki, he is one of the founding members of S.E.E.S.

Female. Height: 166cm. Her Persona is Penthesilea. A student in Class 3-C at Gekkoukan High School. She is the Student Council President and the captain of the fencing club. The only daughter of the current head of the Kirijo Group, a world-leading multinational conglomerate, she is a noble lady carrying the blood of the Kirijo main family. Intelligent and strict, she is a beauty who already exudes the aura of a leader at the young age of 18. On the other hand, because she was raised in a sheltered environment, she can be out of touch with the world and a bit airheaded. At school, a wall tends to form between her and other students, which she occasionally worries about. While she appears to be a cool and rational lady on the surface, her true nature is short-tempered and passionate.

Female. Height: 152cm. She has emerald green short hair and wears a turtleneck of the same color under her uniform. A second-year student at Gekkoukan High School in the class next to the protagonist. Her Persona is Lucia. She is a healing presence who supports the team's activities mentally and has excellent grades. Though she can be timid, she is a strong-willed person with a firm core. She is also forgiving enough to pardon those who bullied her. Her hobby is tinkering with machines. Her Persona excels at searching and information gathering, which Fuuka describes as "feeling the life force."

Technically female. Height: 162cm. Her Persona is Palladion. She has blonde hair, blue eyes, and a large ribbon on her chest as her trademark. Although she is a machine, her face looks almost human. She is the last model of the "Anti-Shadow Special Suppression Weapon" series developed by the Kirijo Group ten years ago as a safeguard against Shadow rampages. She has a unique way of speaking, ending her sentences with "de arimasu" (polite/robotic). She has a bullet-firing mechanism in her fingers; during combat, her fingertips open up from their camouflaged shutter-like state to fire bullets.

Male. His Persona is Castor. Weapon: Axe. Height: 177cm. A third-year student at Gekkoukan High School, currently on leave. He is a childhood friend of Akihiko Sanada, having grown up in the same orphanage. He was an original member of S.E.E.S., but left the group due to a certain incident. He now spends his time alone near Port Island Station, a hangout for delinquents. He is highly respected by the delinquents, likely because he is terrifyingly strong in a fight. For some reason, he wears a knit cap and a long coat even in the summer. In truth, he is kind-hearted and a first-class cook. For some reason, he feels a sense of wariness or distrust toward Ken Amada.

Male. A fifth-grader at Gekkoukan Elementary School. A boy with slightly messy brown hair. He wears an orange hoodie under his uniform, and his casual clothes are often orange as well. His Persona is Nemesis. Weapon: Spear. Height: 140cm. He has a strong sense of justice and is a bit precocious, but he is polite and mature for his age. He also holds a sense of admiration for Akihiko Sanada and "adults" in general.

A rare dog who is a Persona user. He is a Shiba Inu, but due to albinism, his fur is whitish and his eyes are red. Despite his adorable appearance, he has a loyal and masculine personality. He is the quintessential faithful dog. He also shows a caring side toward other dogs, such as bringing his own food to a stray dog who was in a situation similar to his own past. Although he is a Persona user, he is a genuine dog and cannot speak. However, he seems to understand human speech and communicates through Aigis's translation.