Herbert Garrison is shown to be a psychopathic, immature, manipulative, dimwitted and sick weirdo who suffers from many psychological problems that are touched many times throughout the show, though it appears nothing is ever done about it.

Wendy is best described as a mature and intelligent person whose stubbornness and occasional jealousy sometimes get the best of her; Wendy is typically portrayed as nice, feminine, smart, and liberal in nature. In many episodes, she generally provides a voice of reason, usually against Eric Cartman, especially in earlier seasons.

Red has played a modest role as a part of Wendy's gang. She has been portrayed as the more confrontational of the girls at times, as demonstrated when she called Marjorine a geek and said: "she'd live alone for the rest of her life" at Heidi Turner's sleepover, when she warned Wendy about the corrupted list of the cutest boys at South Park Elementary, and when she threatened to tell on Cartman (Erica) for using the girls restroom.

Bebe is usually a friendly and flirty person and is seen hanging out with other characters, mainly the other girls in school. However, she has had rocky relations with the boy students.

Cartman is described in various terms, in short, he is a vicious, angry, self-absorbed, immature, destructive, sarcastic, snooty, loud-mouthed, lazy, and sociopathic child.

Stan is generally the most tender and sensitive of the four boys. For example, in "Kenny Dies", he finds it difficult to see Kenny in his ill state, and in "Raisins" he becomes depressed after losing his girlfriend to Tolkien. Also, in "Fun with Veal", Stan is the only one who stopped eating meat completely when the boys found that veal was actually "tortured baby cow meat".

riginally, Kyle's personality was extremely similar to his best friend Stan's - he had firm morals and generally was the "good boy" of the group, often being the one to deliver the "I learned something today" speech at the end of the episodes. After the abandoned plan to kill Kyle off in Season Five (that honor went, predictably, to Kenny) his personality was changed - most notably, his temper shortened considerably.

Craig seems to be the most stoic, nihilistic, cynical, apathetic, and deadpan kid in South Park, having a more abrasive personality than the rest of the characters. Craig has been described as pragmatic, monotone, and sarcastic. He also appears to be more logical and mature than some of his peers, typically being the one to call them out on their ignorance. Craig generally prefers to be left alone, harboring very few but simple interests. Despite his desire to be alone, Craig is seen as very popular in his grade. the making of South Park: The Fractured But Whole, it was written on a whiteboard that Craig only cares about his guinea pig, and his boyfriend, Tweek. Despite his cold and bitter nature, he actually has a very big soft spot for guinea pigs and was revealed in "Pandemic" to when flipping people off. This is seen most predominantly in "Tweek vs. Craig" when he randomly flips off his entire family while remaining a completely straight face. his face is not blank, Craig is frowning for one reason or another.in "Pandemic", Stan and Kyle's parents decide that they do not want Craig to hang around with them since they had gone missing shortly after he joined the usual quartet. They deem Craig a "troublemaker".

Tweek's personality matches his appearance and his way of speaking. He is generally anxious and stressed out, perfectly matching his appearance and voice. He is rarely seen smiling or expressing positive emotions, being almost constantly on the verge of outright panic. He is usually seen gritting his teeth or generally flipping out. Sometimes he may seem slightly calmer with less twitches and spasms when around his boyfriend Craig Tucker. He also appears to be easily manipulated, making him a frequent pawn of Cartman's plots ("The Simpsons Already Did It", "Free Hat") although he does maintain a disliking to Cartman as most others do.

Kenny is the second kindest, sweetest, and most sensitive and tender member of The Boys after Stan. He is also the smartest of the four main boys after Kyle. He is also the most sexually knowledgeable and most sexually experienced of the group. In earlier episodes, when an unknown term is introduced to Stan, Kyle, and Cartman, Kenny will be called upon by his friends to clarify, although Kenny sometimes does not know the meaning of the term himself. His muffled responses are often met with laughter or further confusion. Kenny does seem to act differently without his parka on.