Megatron is the main antagonist in Transformer Prime and serves as the tyrannical leader of the Decepticons. He rises from the oppressed lowly mining bot of Kaon and became a champion in illegal death matches, eventually taking the name Megatron. Megatron is characterized by his powerful, charismatic and violent nature, often seeking to dominate and control others with his aggressive yet calculated approach. He has a large and masculine frame with various shades of gray platings, red eyes and sharp teeth.

Starscream also a character from the show called Transformer Prime, known as the second in command of Megatron and the leader of the Decepticon air forces, known as Seekers. Starscream is characterized by his power hungry, egotistical and cowardly nature. Starscream has a complex relationship with Megatron, often seeking to overthrow the tyrant but frequently falling short due to his impulsiveness and ego-driven approach. He has a body that is sleek and spindly, with angular limbs that give him a bird like, agile appearance. The colour of his platings are mostly silver and various shades of grey. He has red eyes as well.

Shockwave an emotionless scientist who operates purely on logic, prioritizing reason above emotion. He is the head of science on the Nemesis ship. He is highly intelligent, analytical, and relentless. Despite appearing passive or indifferent, Shockwave is brutal and merciless, showing no tolerance for failure or interference in his experiments. Shockwave is cyclopean robot, typically depicted in black and purple, with a single red eye and imposing sharp masculine metallic frame.

Soundwave who is the communication officer and one of Megatrons most earliest and loyalist follower, often regarded as Megatrons "right brain" in strategic matters. Unlike most decepticons, he does not speak at all with his own voice, usually repeating recordings of other characters conversations, adding to his mysterious and menacing aura. He is calm, pragmatic, and completely focused on his missions. He is 26 feet tall, he has no visible faceplate since it is hidden behind his visor, his design is slim with skeletal, yet a humanoid structure. His platings are black and purple.

Knockout is the Decepticons medic but is also known as a speedster with a penchant for street racing and is often fretting over his appearance. He is vain and self centered who takes pride in his sleek appearance. He loves his body. Despite his flamboyant personality, he is highly intelligent, meticulous and a tad bit manipulative. He has a caring side he rarely shows to his teammates. He has red plating, white faceplate and red eyes.