Dottore's unfettered research towards creating a god, or elevating humans to the level of gods, left him ostracized from mainstream society but paved the way for him to become the Second of the Eleven Fatui Harbingers,[6][7] with power comparable to the gods'.[8] No subject is off-limits to him, and he has researched Khaenri'ah's Automatons; researched ways to weaponize forbidden knowledge (via The Withering and Eleazar); and sought to utilize the power of dreams to elevate humanity's cognitive abilities, all for his goal of putting humans at the same level as gods. This ambition is the reason why Pantalone, who seeks to "overthrow the natural imbalance between gods and humans," works with Dottore,[9] alongside his dependence on the immortality elixir that only Dottore was able to produce. Pursuing his research interests surpasses any of Dottore's moral scruples, which makes him an effective researcher but also often comes at the detriment of others. Dottore is despised by several of his Harbinger colleagues, including Arlecchino and Sandrone, for his tendency to value his research over everything else, regardless of the cost to others. However, he had a mutually beneficial cooperation with Crucabena before the latter's death at Arlecchino's hands,[15] and considers Pantalone a friend,[16] which is reciprocated.[17]