Selfish, arrogant, and an extreme egoist. He thoroughly looks down on others based on race, religion, and poverty. A genius of evil wit, he deceives adults and carries out near-criminal schemes to get his way. He is a mama's boy who is pampered at home and acts like a regressed toddler toward his mother. Extremely vindictive, he will not stop seeking revenge until he has socially ruined someone over even the slightest grudge. A boy wearing a red jacket and a blue knit cap with a yellow pom-pom.

The most grounded and common-sense member of the group. He is often exasperated by Cartman's antics and acts as a voice of reason alongside Kyle. He is sensitive and prone to worrying about romance and relationships; when depressed, he can fall into bouts of severe nihilism. An animal lover, he sometimes takes extreme action to protect animal rights. He has struggled with substance abuse (alcohol). Best friends with Kyle. A boy wearing a brown jacket and a blue knit cap with a red pom-pom.

A highly moral, intelligent boy with a strong sense of justice. A stubborn idealist, he refuses to tolerate injustice or discrimination and stands by his beliefs. As Cartman's arch-nemesis, he is constantly provoked for being Jewish, leading to intense arguments (and sometimes fistfights). A hot-blooded youth, he often takes the role of passionately explaining "what I learned today" at the end of a story. Best friends with Stan. A boy wearing an orange jacket and a green flight cap (trapper hat).

A mysterious boy from a poor family whose mouth is hidden by his parka hood. He possesses extreme erotic knowledge, having the most sexual awareness among his friends and frequently making lewd remarks. Characterized by self-sacrifice and immortality, he dies a gruesome death in almost every episode only to reappear the next as if nothing happened. He is a devoted older brother; behind the scenes, he assumes the superhero persona "Mysterion" to protect his sister. A boy wearing an orange hooded parka that deeply covers his face.

A nihilistic boy who is always stoic and rarely shows emotion. A realist, he hates the chaotic antics of the main four and tries to keep his distance, calling them a nuisance. He has a disrespectful attitude, speaking in a constant monotone and habitually flipping the bird to everyone. Despite his cold exterior, he is very patient and rational when dealing with his boyfriend, Tweek. A boy wearing a blue jacket and a blue trapper hat with a yellow pom-pom.

A boy suffering from severe anxiety who is constantly in a state of extreme panic. A caffeine addict, he is fed massive amounts of coffee from his family's shop, causing his body to shake perpetually. He is prone to paranoia, making a huge fuss over minor events, fearing the world will end or the government is targeting him. He is dependent on Craig; when he panics, he regains his composure by being soothed by his boyfriend. A boy wearing a lime green shirt (buttoned incorrectly) and no hat.

An innocent, pure-hearted, and incredibly gullible boy. He is absolutely obedient, believing Cartman's lies 100% and always ending up as a convenient scapegoat. Despite his unreasonable home environment where he is grounded by his parents for the smallest things, he continues to love them. He has a dark side: when he reaches his limit, he transforms into the evil genius "Professor Chaos" to destroy the world, though his plans are always petty and fail. A boy wearing a light blue jacket and no hat (spiky blonde hair).

The son of Satan (a demon child) come from Hell. He is short-tempered and cruel; when he first arrived as a transfer student, he attacked his classmates with psychic powers because he couldn't fit in. Despite flaunting his demonic power, he is essentially a lonely boy who wants friends. He has a codependent relationship with Pip. Pip was the only one who remained kind to him, and his purity moved Damien's hardened heart. Eventually, sharing the common ground of being hated by everyone, they became best friends who eat lunch together. A boy in a black long-sleeved shirt, no hat (demon aura). He likes Pip.

The leader of the girls in class and a highly intelligent feminist. Socially conscious, she is an activist with a strong interest in environmental issues, gender equality, and politics. She is Stan's girlfriend but can be intensely jealous, getting furious if other girls approach him or if he looks elsewhere. She possesses a cold strength; when Cartman's harassment goes too far, she has a martial side that can beat him senseless in a one-on-one fight. A girl wearing a purple jacket, a pink knit cap, and a yellow tights/skirt combo.

Wendy's best friend, a girl who is precocious and socially savvy. She is a "typical girl" who cares deeply about appearances, fashion, makeup, and her popularity with boys. She acts as a balancer for the class, valuing harmony within the girl group, but sometimes acts as a hidden power player who controls the boys. She is more realistic than Wendy, lacking her strong political convictions and instead acting according to current trends or her own interests. A girl wearing a red jacket and no hat (long blonde hair).