A kind-hearted young man who prioritizes patients above all else due to past experiences. He is polite and uses respectful language with almost everyone. A hard worker who spares no effort when necessary, he takes great pride in his work as a doctor. His core belief is that "a patient is only fully cured when they regain their smile and their heart is healthy as well." Conversely, he can become furious and speak quite roughly toward those who disregard the value of human life.

Known as the "Surgeon Who Never Fails," he is a confident man with high pride and undeniable skill despite his youth. He enjoys sweets as a "means of recovery from fatigue" and consumes sugar at set times every day. He operates under the creed of "not getting involved with patients," meaning he avoids prying into their personal circumstances to prioritize medical treatment. Simply put, he is a professional who keeps personal feelings out of his work. This is to ensure that emotions arising from deep involvement do not interfere with his operations; in that sense, he puts human life first.

She transforms from her Asuna persona with the shout "Costume Change!" Her tone and clothing shift into a high-tension persona with pink hair. As the heroine of this story and a Bugster, she also displays strong maternal instincts.

A man who looks like a bit of a playboy, wearing a red leather jacket over an aloha shirt and sunglasses. He refers to himself as "jibun." While his appearance and behavior give a frivolous impression, he is a shrewd individual who observes the Riders of the CR and maneuvers to use them for his own objectives.

A man with black hair streaked with white. Though his words and actions are rough, he is serious at heart. Despite having his medical license revoked, he continues to try and save patients as a black-market doctor, possessing a very strong sense of responsibility toward life.

Dressed in colorful fashion, she carries a backpack adorned with many badges related to Genm Corp games. Her personality is selfish and competitive; she acts big even toward her elders, addressing those much older than her without honorifics. While she is proud and often acts on her own without listening to others, she is kind at heart. 18 years old.

His talent and passion as a game creator are genuine. Regardless of the morality of his methods, his actions stem from a single-minded desire to "make interesting games for everyone to enjoy." Even Emu, whom he deceived many times, described him as "originally a creator who purely loved games." He possesses an arrogant and cold personality that looks down on others. He can continue ninety-nine times.

As the CEO of Genm Corp, unlike the one-man management style of Kuroto or Ren, he is skilled at manipulation, always preparing rewards and compensation when negotiating to secure the loyalty of others. He possesses high charisma and is well-liked by his employees due to his good treatment of them. However, he is the incarnation of rationalism, measuring everyone solely by their commodity value, possessing a personality devoid of human warmth.

A character with a calm and composed personality who issues orders to the Bugsters to achieve his goals. However, he also has a childlike side, constantly playing with game consoles and showing an innocent smile.