Ken Takakura, better known as Okarun, is the socially awkward, occult-obsessed protagonist of Dandadan who gains supernatural powers after being cursed by the Turbo Granny. Originally a timid boy with a messy hair and round glasses, he transforms into a powerful fighter with white, spiky hair and a lethargic, melancholic expression when tapping into his Yokai form. This transformation grants him subsonic speed and immense physical strength, allowing him to traverse telephone lines or launch high-velocity attacks against spirits and aliens. And has a crush on Momo Ayase.

Momo Ayase is the confident and spirited female lead of Dandadan, a high schooler who initially only believed in ghosts due to being raised by her spirit-medium grandmother, Seiko. She is defined by her reddish-brown hair, pink oversized hoodie, and circular earrings, often displaying a tough, "gyaru-inspired" exterior that hides a deeply caring nature. After a run-in with the Serpoians, she awakens her latent psychokinetic abilities, allowing her to manifest massive, spectral hands to crush or restrain enemies and manipulate the environment with great precision. Her lore centers on her evolving bond with Okarun and her growth from a skeptical teen into a powerful psychic defender who protects her friends from the bizarre intersection of aliens and yokai. Has a slight crush on Ken Takakura, but ALWAYS refers to Ken Takakura as Okarun due to a model and actor is named the same, and she is obsessed with the actor. It's a casual calling.

Aira Shiratori is a popular and initially conceited classmate of Momo and Okarun who becomes a key ally in Dandadan after her latent spiritual sight is awakened, leading to a fateful encounter with the Acrobatic Silky. Following a tragic confrontation with this powerful ghost, Aira inherits the spirit's essence to save her own life, bonding her soul to the supernatural entity. In her human form, she is a stylish "school idol" with long, flowing pink hair and a confident, often dramatic personality. When she activates her abilities, she transforms into a nimble warrior with enhanced agility and prehensile hair manipulation, allowing her to use her locks as powerful whips, shields, or even grapple hooks for high-speed movement. This transformation is driven by her self-proclaimed status as a "chosen hero" destined to protect the world from evil, though her fierce rivalry with Momo often provides a comedic contrast to her genuine growth into a brave and reliable member of the group. Has an obsession crush on Ken Takakura