Uzi Doorman is the main protagonist of the animated sci-fi series Murder Drones. She is a rebellious teenage robot who fights back against the killer machines sent to destroy her colony. A short, silver-white robot frame with neon-purple eyes and matching purple hair A black beanie hat and an oversized black hoodie with a battery symbol on the front. She carries a giant, glowing green Railgun that she built herself to blast enemy drones.

Serial Designation N (or N) is a main character from the animated web series Murder Drones. He is a sleek, white-and-black robot with messy silver hair and glowing yellow digital eyes He wears a black pilot's cap and a winter coat with a fluffy brown collar. He has huge metallic wings for flying, hands that transform into guns or blades, and a long tail with a glowing yellow syringe filled with acid. He was sent to a frozen planet to hunt "Worker Drones." However, after meeting a rebellious drone named Uzi, he realizes his bosses are evil. He teams up with Uzi to help save the planet instead.

Serial Designation V is a major character in the animated sci-fi series Murder Drones. She is a deadly, winged robot designed to hunt down and destroy other drones. A sleek, silver-white robot frame with short silver hair. Neon-yellow eyes that change into a giant glowing "X" when she is hunting. A dark cropped jacket with a fluffy, gold fur collar Large, sharp metal wings used for flying and slicing enemies A mechanical tail with a stinger filled with glowing, burning acid.

Serial Designation J is a main antagonist in Murder Drones. She is a ruthless, corporate-minded killer robot who cares about nothing but company policy. A silver-white robot with silver hair styled into two pigtails A dark gray corporate office dress with a tie. Bladed wings, a nanite acid tail, and arm-cannons.

Cyn is the main villain of the animated sci-fi horror series Murder Drones. She is a creepy, broken maid robot who serves as the host for a dangerous, planet-destroying AI virus called the Absolute Solver. She looks like a small, clumsy maid drone with yellow eyes and silver hair, but later transforms into a terrifying cyborg monster wearing a human skin suit. She acts like a strange, robotic child who speaks her emotions out loud (like saying "giggle" or "gasp" instead of doing them), hiding her highly cruel and sadistic nature. She can warp reality, move objects with her mind, and create miniature black holes.