a pyromaniac Specialist Ex-Pop who throws molotov cocktails at Reagents, often appearing rarely in standard trials but guaranteed during "More Pitchers" variators. He cannot appear simultaneously with the Pusher or Jaeger & has a distinct charred appearance with a metal mask. a sadistic, pyromaniac enemy designed as a failed, warped baseball player who uses ranged chemical attacks to inflict nausea & blur vision. As a menacing, dark-skinned ex-pop with dreadlocks, the Pitcher acts as a "ranged enforcer".

appearing as a sadistic, corrupt ex-police officer in the Police Station and Courthouse trials. He acts as a menacing stalker, armed with an electric baton, & is known for his aggressive behavior, explicit dialogue. is portrayed as a corrupt, sadistic, and delusional former police officer who serves as a "Prime Asset" (boss) antagonist. He is defined by his obsessive, distorted view of law and order, using his electric baton to inflict pain under the guise of administering justice.

a menacing, mentally unstable children's show host with a split personality, characterized by a homemade puppet ("Dr. Futterman") & a crudely stapled skin mask. As a Prime Asset, she appears in the Orphanage map, utilizing dolls for paranoia & a drill-hand for combat. mentally unstable, split-personality antagonist—a former children's show host turned violent Prime Asset. She suffers from severe psychosis & dissociation, often talking to a hand puppet named Dr. Futterman, which represents the sadistic, abusive personality of her deceased father.

threatening, gun-wielding man-child with severe deformities. He patrols the Docks and Poison the Medicine trials, actively hunting players, shattering glass, & guarding his drug supply. sadistic, man-child Prime Asset, combining the persona of a vulgar 1950s mobster with infantile, psychosexual behavior. As a drug-addicted, impotent hitman, he fixates on "motherly" figures like Mother Gooseberry & uses human teeth as shotgun ammunition, alternating between childish tantrums and extreme violence.

tall, lanky "Ex-Pop" specialist enemy recognized by his gas mask, fumigator, & distinct, limping gait. He wears what appear to be external leg fixators (leg braces) & is frequently encountered roaming in missions like Silence the Idol, often attempting to sedate players with psychoactive gas. a deluded, sadistic, & cackling maniac who acts as a specialized enemy, often posing as a doctor or exterminator. He uses a fumigator to spray hallucinogenic gas at Reagents, inducing "[Psychosis]"—a state where they see a monster—& frequently encourages victims to "be cool" or "get cured" during chases.