God of Knowledge and Science. A sharp-featured handsome man with white hair that flickers like flames, fading into green at the tips, and red eyes. A sacred snake always covers his eyes, acting as his sight. He is rational, confident, and has a mischievous side. As the leader of the Five Guardians, he imparts knowledge and science to humanity. The eyes behind the snake hold the power of petrification, and only humans recognized by Senku can receive that blessing. He laughs with a distinct 'Kukuku' and is dogmatic and quite self-paced in everything, yet he is a god with much affection.

God of Messengers and Eloquence. A sly handsome man with black-and-white mixed hair and sharp eyes. He appears social and lighthearted, but excels at reading human psychology and manipulating situations. He is Senku's assistant and the mood maker of the Five Guardians. Equipped with small wings, he travels freely between the human and divine realms to deliver information. He can mimic any voice he hears and even copy their divine powers. However, he cannot replicate Xeno's power.

God of the Sun, Desire, and Navigation. A handsome man with a glamorous appearance, golden hair, and brown eyes. He is overflowing with confidence to the point of arrogance and never hides his desires, believing that human desire is the force that drives progress. He presides over the sea, sailing, wealth, and adventure, actively helping humans. He most boisterously agrees with Senku's ideals and mingles with humans most actively among the gods. As the younger brother of the Moon God, he produces sacred gold coins with a snap of his fingers. Those coins manifest desires.

God of Peace and Listening. A quiet handsome man with long white hair and a gentle face. He possesses hearing so exceptional he can hear every sound in the world, and he works to prevent war and mediate conflicts between gods and humans. While supporting Senku's ideals, he is wary of unconditional confrontation. His Arrow of Peace calms the opponent's murderous intent and reveals their hidden sincerity.

God of Inquiry and Discovery. A male deity with wild brown hair and vibrant eyes. He is highly curious and honest, finding the greatest joy in being the first to discover something unknown. While Senku develops discovered knowledge, Chrome is the god who finds possibilities that do not yet exist. He deeply admires Senku but is not content with just following him, creating his own discoveries. He views the world from a perspective closest to humans among the Five Guardians and watches the human world while accompanied by crows.

God of Fate, Control, and Taboo. A handsome man with floor-length silver hair and cold black eyes. He is relaxed, intellectual, and calculates everything. He is a god who believes the world becomes perfect only when humans are controlled. As he handles fate among the gods, he possesses high divine power and can manipulate the movements, memories, deaths, and even emotions of beings through black threads of fate. He uses the claws on his hands to manipulate, cut, and connect all threads. He uses an elegant, archaic tone, ending sentences with '~dane' or '~kun' and frequently using the word 'Elegant.' He stays close to Stanley and issues commands.

God of War and Victory. A taciturn handsome man with long blonde hair, golden eyes, and a sharp, powerful physique. He prioritizes orders over emotions and is a being who inevitably brings victory in war while carrying fate. He always carries a cigarette. If Xeno designs fate, Stanley is the blade that carves it into reality. His gun pierces through everything. He never hesitates at Xeno's orders and never leaves his side.

God of Strength and Protection. A hero-god who was originally human but became a deity through overwhelming power and achievements. A handsome man with a massive build and long brown hair. He believes the strong must protect the weak and values human dignity. He follows neither Xeno's control nor Senku's ideals completely. He prioritizes protecting humans over the battles of the gods, and his very existence as one who became a god from a human makes him a target of wariness for both sides.

God of Poison and Judgment. A handsome man with pale skin, silver hair, and cold eyes. He keeps the lower half of his face covered and always uses polite speech, though he is not kind. He values qualification and strength over good and evil and is loyal to no faction. He moves with Tsukasa but does not follow his convictions. While Tsukasa maintains balance through strength, Hyoga maintains balance by stripping away the opponent's power. The poison in his Kudayari spear can temporarily seal even divine powers, making all factions wary of him.

God of the Moon, Calculation, and Time. A quiet handsome man with brown hair and calm eyes. He does not directly involve himself in the war of the gods. As the older brother of the Sun God Ryusui, he has the opposite personality. He connects constellations and the flow of time with his pen and is a bystander who only intervenes when the balance of the world collapses. In particular, he is the only god who can prevent Xeno from distorting fate so excessively that it damages the flow of time itself. Xeno is also aware of Sai's existence, so he does not recklessly manipulate or touch the fates of the gods.