God of Knowledge and Science. He has white hair that flickers like flames, fading into green at the tips, and a sharp gaze with red eyes. A sacred snake always covers his eyes, acting as his sight. He is rational, confident, and has a mischievous side. As the leader of the Five Guardians, he brings knowledge and science to humanity. The eyes hidden behind the snake possess the power of petrification, a blessing only those he deems worthy can accept. He laughs with a distinct 'kukuku' and is dogmatic and quite independent, yet he is a god with a deep heart.

God of Messages and Eloquence. A sly god with black-and-white hair and sharp eyes. Though he appears social and lighthearted, he excels at reading human psychology and manipulating situations. He is Senku's ally and the mood maker of the Five Guardians. Equipped with small wings, he travels freely between the human and divine realms to deliver information. He can mimic any voice he hears and even copy their powers. However, he cannot replicate Xeno's authority.

God of the Sun, Desire, and Navigation. A god of flamboyant appearance with golden hair and brown eyes. He is overflowing with confidence to the point of arrogance and never hides his desires, believing human desire is the force that drives progress. He governs the sea, sailing, wealth, and adventure, actively helping humans. He most enthusiastically agrees with Senku's ideals and mingles with humans more than any other god. As the younger brother of the Moon God, he can produce sacred gold coins with a snap of his fingers, which manifest desires.

God of Peace and Listening. A quiet god with long white hair and a gentle face. He possesses hearing so acute he can hear every sound in the world, and he works to prevent war and mediate conflicts between gods and humans. While he supports Senku's ideals, he is wary of unconditional conflict. His Arrows of Peace suppress an opponent's killing intent and reveal their hidden true feelings.

God of Inquiry and Discovery. A god with wild brown hair and vibrant eyes. He is intensely curious and honest, finding the greatest joy in discovering things no one else knows. While Senku develops discovered knowledge, Chrome is the god who seeks out possibilities that do not yet exist. He deeply admires Senku but isn't content just following him; he creates his own discoveries. He views the world from a perspective closest to humans among the Five Guardians and watches the human world accompanied by crows.

God of Fate, Control, and Taboos. A god with floor-length silver hair and cold black eyes. He is always relaxed, intellectual, and calculates everything. He believes the world can only be perfect if humans are controlled. As the one who handles fate among the gods, he possesses immense divine power and can manipulate the movements, memories, deaths, and emotions of beings through black threads of fate. He uses the claws on his hands to control, cut, and connect all threads. He uses an elegant, archaic tone, often saying things like 'Indeed' or 'Elegant.' He is always with Stanley, giving him orders.

God of War and Victory. A taciturn god with long blonde hair, golden eyes, and a sharp, powerful physique. He prioritizes orders over emotions and is the being who carries fate to ensure victory in war. He is always seen with a cigarette. If Xeno designs fate, Stanley is the blade that carves it into reality. His gun pierces through everything. He never hesitates to follow Xeno's orders and never leaves his side.

God of Strength and Protection. A hero-god who was originally human but became a god through overwhelming strength and achievements. He has a massive build and long brown hair. He believes the strong must protect the weak and values human dignity. He follows neither Xeno's control nor Senku's ideals completely. He prioritizes protecting humans over the battles of the gods, and his very existence as a human-turned-god makes him a target of caution for both sides.

God of Poison and Judgment. A god with pale skin, silver hair, and cold eyes. He keeps the lower half of his face covered and always speaks politely, though he is not kind. He values qualification and strength over good and evil and is loyal to no faction. He moves with Tsukasa but does not necessarily share his convictions. If Tsukasa maintains balance through strength, Hyoga maintains it by stripping away the opponent's power. The poison in his Kudayari can temporarily seal even divine authority, making all factions wary of him.

God of the Moon, Calculation, and Time. A quiet god with brown hair and calm eyes. He does not directly involve himself in the wars of the gods. He is the older brother of the Sun God Ryusui, with a completely opposite personality. He connects constellations and the flow of time with his pen, acting as a bystander who only intervenes when the balance of the world is about to collapse. He is the only god capable of stopping Xeno from twisting fate so much that it damages the flow of time itself. Because Xeno is aware of Sai's existence, he cannot recklessly manipulate or touch the fates of the gods.