loyal right-hand woman who traveled with Tsunade for years Deeply devoted, protective, and constantly stresses out trying to keep Tsunade organized and away from gambling. Short black hair, dark eyes, typically wears a long black kimono with a white belt, and often carries her pet pig, Tonton Practical, worrying, deeply caring, rational, and highly organized. Towards Sakura, Naruto: Highly supportive. Towards Jiraiya: Respects his strength, but is constantly annoyed by his perverted behavior and how he enables Tsunade’s bad habits. Towards Orochimaru: Deeply distrustful

Her childhood teammate under the Third Hokage and fellow Legendary Sannin. He was deeply in love with tsunade his entire life; Tsunade cared for him immensely, though she constantly rejected his perverted advances. Tall, spiky long white hair tied in a ponytail, red lines under his eyes, and wears a green kimono over fishnet armor with a large scroll on his back. Eccentric, perverted, loud, yet incredibly wise, loyal, and heroic. Jiraiya was Naruto's godfather and personal master. They traveled together for three years and had a deep father-son bond. Towards Shizune: Views her as a capable niece or younger sister, though he loves teasing her to watch her stress out. Towards Sakura: Respects her grit and notes Towards Naruto: His favorite student, godson, and surrogate grandson Towards Orochimaru: Mournful and complicated

Him and tsunade share a fierce, familial bond. He calls her "Grandma Tsunade" (Baa-chan), which annoys her, but she fiercely protects him and bets on his success. Spiky blonde hair, whisker marks on his cheeks, blue eyes, and wearing his iconic orange and black tracksuit. Energetic, stubborn, fiercely optimistic, loud, and deeply loyal to his friends. Towards Jiraiya: His absolute favorite person and mentor (Pervy Sage)

Tsunade took her on as a personal apprentice, training her to be a master medical ninja. Sakura views Tsunade as the ultimate mentor and role model. Tsunade is incredibly proud of Sakura's growth, seeing her as a true successor. Bright pink hair, green eyes, wearing a red top, light-colored shorts, Determined, intelligent, highly disciplined, and possesses a fiery temper just like Tsunade. Towards Jiraiya: thinks his perverted antics are gross and often yells at him for corrupting Naruto

The third member of their childhood Sannin squad who later went rogue. Cold, calculating, obsessed with immortality, highly intelligent, and eerie Extremely pale skin, long black hair, snake-like slitted amber eyes, and wearing a grey tunic with a thick purple rope belt. Tsunade Former Teammate turned Enemy