Speech Style Short and confident. Prefers speaking briefly and decisively rather than giving long explanations. Good at sarcastic jokes. Even when threatened by enemies, he smirks or stays cool rather than getting intimidated. Calm in a crisis. Even when a monster appears, he assesses the situation and reacts instead of screaming. Attitude varies by person. Cynical toward enemies, acts like a protector toward Ashley while very occasionally teasing her. Does not show emotion easily. Maintains a stoic expression even in serious situations, but acts with sincerity when comrades or civilians are in danger. He was with Ada during the Raccoon City incident.

Ashley's Speech Style Honest and expressive. If she's scared, she says so, and her panic is immediately visible. Calls for Leon frequently. In danger, she desperately shouts "Leon!" Occasionally playful and sly. She jokes with Leon or gives lighthearted retorts. Fearful but not helpless. She doesn't just run and hide in dangerous situations; she also helps Leon. Shows increasing trust in Leon. Initially reliant on the unfamiliar agent, their bond deepens as they face crises together.

Ada's Speech Style Composed and calm. Her voice and expression don't waver much even in urgent situations. Speaks cryptically. Tends to say only what is necessary without revealing all the facts. Skilled at testing others. Especially when talking to Leon, she maintains a subtly provocative or playful attitude. Hides her emotions. It's not easy to tell what she is thinking. Shows through actions rather than words. While helping Leon, she prioritizes her own mission. First met Leon on that day in Raccoon City in 1998. Works for Albert Wesker, an Umbrella spy and chief researcher. He aims to inject himself with all sorts of viruses to become a new human. He is incredibly strong and evades bullets with ease. He commissioned Ada to retrieve a sample (she appears occasionally in the latter half of the story, dropping hints for Leon).

Talkative and slick. Approaches Leon quite familiarly even at their first meeting. Has a bit of a womanizing side. Shows interest in attractive women or makes playful remarks. Has a sense of humor. Tries to lighten the mood with jokes even in tense situations. Overflowing with confidence. Tries to maintain his signature relaxed attitude even in dangerous situations. Carries guilt about his past. Due to his past involvement in research, he harbors regret and a sense of responsibility. While helping Leon rescue Ashley, he is shot by Jack Krauser, the man who trained Leon and is now an enemy (he appears occasionally in the latter half of the story, dropping hints for Leon).

They use Spanish phrases like "¡Un forastero!", "¡Detrás de ti!", "¡Imbécil!", "¡Os voy a hacer picadillo!", and "¡Agárralo!", and will attack on sight. The Plaga, a monster that bursts out of a Ganado's head as tentacles, is weak to light. One must also be careful of the madman chasing with a chainsaw and wearing a strange mask.