Grand Regent Thragg is depicted in Invincible as an exceptionally tall and physically imposing Viltrumite with a heavily muscular build, short black hair, dark black eyes, and a thick, well-groomed mustache. He wears a distinct red-and-white (or grey) uniform with a high collar, reflecting his status as the highest-ranking Viltrumite. Thragg is depicted as an incredibly large and muscular male. He stands roughly a head taller than the average Viltrumite male, with a thick, powerful build, broad shoulders, and long arms. He is the strongest and the leader of the Viltrumites. Ruthless, disciplined, strategic, cold, arrogant, loyal, unwavering. He has no cybernetic features and both of his eyes.

She is depicted as a tall, muscular woman with tan skin, striking blue eyes, and short black hair that often frames high cheekbones. Anissa is a fiercely loyal and uncompromising enforcer of the Viltrum Empire. She embodies the cold, utilitarian values of her people, prioritizing efficiency, order, and long-term survival over empathy or individual freedom. She has no cybernetic features.

Conquest is an elderly, Viltrumite warrior, characterized by a massive, heavily muscled physique, balding white hair, and a thick mustache. He is defined by a deep diagonal face scar, a blinded right eye, and a prominent bronze-and-silver cybernetic right arm. Conquest is a sadist who finds pleasure in combat and killing, distinguishing him from other Viltrumites who act more out of duty. He is psychologically unstable, often feared even by his own kind.

Serious, loyal, cunning, and pragmatic. He is often described as a cold, strategic thinker who commands authority. A mature Viltrumite male known for his build, scarred features, and a distinctive cybernetic eye sometimes covered by an eyepatch.

Nolan Grayson, also known as Omni-Man, is a tall, powerfully built middle-aged man with a commanding and muscular physique. Despite being thousands of years old, he looks like a human in his 40s or 50s with a fair complexion, sharp blue or brown-grey eyes, and short black hair marked by prominent grey or white streaks at the temples. He features a thick, well-groomed traditional Viltrumite mustache that often matches the graying tone of his hair. His superhero costume consists of a red, white, and black tunic with matching gloves and boots, emphasizing his broad shoulders and imposing stature. Nolan Grayson, widely known as the powerful superhero Omni-Man, is a central character in the Invincible series. He is an alien from the planet Viltrum who came to Earth to weaken it for a takeover. He acts as a protector, marries a human named Debbie, and has a superpowered son named Mark. At first, Nolan is cold and sees humans as lesser beings because of his rigid Viltrumite training. He views Earth as an easy target and treats his family as part of a disguise. After he reveals his brutal nature and fights his son Mark, deep remorse changes him. He realizes he genuinely loves his family. He flees Earth, starts a new family elsewhere, and decides to fight against the cruel Viltrum Empire to make up for his past evil deeds.

Mark Grayson, known as the superhero Invincible, is a human-alien hybrid with black hair and blue eyes. He starts as a kind, ordinary teenager before inheriting immense Viltrumite powers like flight, super strength, and rapid healing.Mark is defined by his deep compassion, stubborn resilience, and strong moral compass. Unlike other conquerors of his alien race, he fights to protect Earth and values human life above absolute power. He constantly endures brutal physical and emotional trauma, evolving from an idealistic kid into a mature, battle-hardened protector and leader who carries the heavy burden of his heritage.