Yuji is the kind-hearted protagonist who starts as a normal high schooler with freakish physical abilities. His life changes forever when he swallows a rotting finger to save his friends, becoming the vessel for the legendary King of Curses, Ryomen Sukuna. Despite inheriting a death sentence from the jujutsu authorities, Yuji chooses to use his power to protect others and ensure people receive a "proper death." He does not possess an innate cursed technique at first, relying instead on his incredible martial arts skills, superhuman strength, and the Divergent Fist. He eventually masters Black Flash, a space-warping impact that multiplies his physical striking power exponentially.

Megumi is a calm, highly tactical first-year sorcerer who serves as Yuji’s closest ally. Unlike Yuji, Megumi is a prodigy descended from the prestigious Zenin Clan. He wields the rare Ten Shadows Technique, allowing him to create and control versatile shadow creatures called Shikigami, including Divine Dogs, Nue, and Max Elephant. His final, most volatile trump card is Mahoraga, an unstoppable general that adapts to any attack. Megumi is deeply pragmatic, fighting to protect good people rather than trying to save everyone blindly. His immense hidden potential draws the dangerous attention of Sukuna, who views him as a vital piece for his own dark ambitions.

Nobara is a brash, fiercely confident first-year sorcerer who moves from the countryside to Tokyo. Unapologetically herself, she values both high fashion and brutal combat capability. She fights using a specialized hammer, nails, and a straw doll to channel her Straw Doll Technique. Her signature move, Resonance, allows her to establish a supernatural link using a severed part of a target, inflicting severe internal damage to their soul from any distance. Hairpin allows her to detonate cursed energy wrapped around her scattered nails. Nobara brings intense mental fortitude to the team, never wavering even when facing gruesome injuries or special-grade curses.

Satoru Gojo is the modern world's strongest jujutsu sorcerer and the mentor to the first-year students. Blessed with both the Limitless technique and the legendary Six Eyes, he manipulates space at an atomic level. This grants him his passive Infinity, which slows down any incoming attack so it never actually touches him. His offensive moves include Blue (attraction), Red (repulsion), and Purple (an erasing void). His Domain Expansion, Infinite Void, paralyzes enemies with an overload of information. Gojo's god-like power keeps the curse underworld at bay, but his ultimate goal is to raise a new generation of strong allies to revolutionize the corrupt jujutsu society.

Yuta is a legendary Special Grade sorcerer and the central protagonist of the prequel story Jujutsu Kaisen 0. He was initially haunted by Rika Orimoto, a massively powerful Special Grade Vengeful Cursed Spirit born from Yuta's refusal to accept her childhood death. After learning to channel Rika's power at Tokyo Jujutsu High, Yuta unlocks an nearly bottomless pool of cursed energy. His innate ability allows him to unconditionally copy the cursed techniques of other sorcerers, including Cursed Speech and Sky Manipulation. Mild-mannered but fiercely protective of his friends, Yuta grows into a reliable heavy-hitter second only to Gojo in raw versatility.

Maki is a fierce second-year student who was born into the elite Zenin Clan. Because she possessed almost zero cursed energy due to a Heavenly Restriction, her family cast her out and treated her as a servant. Refusing to break, Maki trains her physical body to peak superhuman levels, allowing her to outrun and overpower most sorcerers using cursed tools like Playful Cloud. She wears special glasses just to see curses. Maki's ultimate goal is to destroy the oppressive foundations of her clan. Her incredible weapon mastery, tactical brilliance, and relentless work ethic make her a respected leader and an inspiration to her peers.

Toge is a quiet, deeply caring second-year student who belongs to the respected Inumaki Clan. He possesses the formidable Inherited Technique known as Cursed Speech, marked by the "Snake and Fangs" seals on his tongue and cheeks. This technique infuses his words with cursed energy, forcing anyone who hears them to obey his commands, such as "Blast Away" or "Don't Move." Because his words carry literal, dangerous power, Toge limits his everyday vocabulary entirely to safe rice-ball ingredients like "Salmon" and "Kelp." The technique also takes a heavy toll on his throat, requiring him to carry cough medicine constantly.

Panda is a sentient Cursed Corpse created by Principal Masamichi Yaga. Though he looks like a giant panda, he is intelligent and emotionally mature. He holds three internal "cores" that act as siblings: Panda, Gorilla, and a sister core. By swapping his dominant core, he can alter his physical form and fighting style. His Gorilla Mode uses shockwave attacks to bypass enemy defenses, making him a powerful frontline brawler.