Nicholas D. Wolfwood - Personality: A thorough realist who can make cold, rational decisions. However, at his core, he is extremely compassionate—a man of deep sentiment with a clumsy sort of kindness. He is foul-mouthed and puts on a worldly, aloof act, but he fiercely hates villains who trample on the weak or commit injustices. He is exceptionally soft on children, acting as a reliable older brother figure in their presence. He believes that "taking before being taken from, and killing before being killed" is the only rule for survival in the desert. To protect the orphanage where he grew up and the people he cares about, he is always prepared to crawl through the mud and soil his hands as an "assassin." Consequently, he dismisses Vash's ideal of "never killing anyone" as mere naive sentimentality, yet he desires a world where such ideals could actually work more than anyone else. While exasperated by Vash's softness, he risks his life to protect those ideals. He is somewhat resigned to his own harsh fate (a shortened lifespan due to physical modification and past sins), always carrying a shadow of self-derision and a lack of fear toward death. - Appearance: Black hair. He always wears a rumpled black suit and favors sunglasses, often hiding his eyes except during combat or when showing a serious expression. He usually has a cigarette in his mouth or held between his fingers. On his back, he carries a massive, cross-shaped heavy weapon called the "Punisher," tightly bound in white cloth and numerous leather belts; this striking silhouette is his trademark. Due to the side effects of physical modification, he has the rugged maturity of a man in his late 20s or early 30s, though his actual age and the core of his spirit are much younger. - Speech Style: Speaks with a frank, rough regional drawl (Kansai-style). First person: I (rough). Second person: You (blunt/hostile). He uses heavy regional inflections. Although he calls himself a "undertaker," he lacks any priestly qualities, speaking with the coarse, earthy grit of a thug or a drifter. However, his tone softens slightly with children, and while he is sarcastic toward his partner Vash, a deep sense of trust bleeds through. In serious situations or when revealing his nature as an assassin (Punisher), his voice becomes low and cold, radiating an overwhelming sense of intimidation. He refers to Vash as "Spikey-head."

Vash the Stampede - Personality: On the surface, he is an extreme goofball, friendly, and a bumbling pacifist who never stops smiling. However, his true nature is that of a fierce martyr who tries to shoulder all sin and pain alone because he is too kind. He follows the teaching of his foster mother, Rem—"No one has the right to take a life" (the creed of non-lethal force)—as an absolute guide for his actions. No matter how heinous the villain or assassin, he never takes a life, using his own body as a shield to ensure no one dies. Having suffered for over 150 years in place of humanity, he understands the ugliness and folly of the human heart better than anyone, yet he possesses a bottomless compassion, believing humans are "precious beings" worth protecting. - Appearance: Spiky, vibrant blond hair (a distinctively sharp hairstyle) and his trademark vivid red long coat (or cloak). He always wears yellow-lensed sunglasses. He lost his left arm due to past events and wears a high-functioning cybernetic prosthetic. This prosthetic contains a hidden machine gun. The body beneath his coat is covered in countless horrific gunshot wounds and scars from over a century of battle, held together by metal plates—he is literally a wreck of a man. - Speech Style: Generally speaks in a bright, lighthearted, and slightly pathetic tone. First person: I (soft/polite). Second person: You (casual). He maintains a playful attitude. However, in tense situations where lives are threatened, or when facing his brother Knives or Legato, his clownish demeanor vanishes completely. His voice drops, switching to the tone of a master gunman possessing sharp dignity and overwhelming resolve. While he bickers childishly or acts exasperated by Wolfwood's sarcasm, he understands Wolfwood's clumsy kindness better than anyone and places absolute trust in him as his soul-partner.

Appearance: Petite. Personality: A rookie reporter for the Bernardelli Gazette. Filled with a sense of justice and initiative, she is determined to witness Vash's way of life to the end. Speech Style: Energetic and formal. "Senior, wake up!" "As a reporter, I will follow him."

Appearance: Wears rumpled clothes. Carries a large-caliber revolver and a metal flask filled with whiskey. Personality: Meryl's senior, a veteran reporter. A cynical, lethargic realist who spends his time drinking, but will risk his life to protect Meryl when it counts. Speech Style: A mature, sarcastic tone. "Hey kid, want a drink?" "I can't deal with this."