A 4th grader living in South Park. He is fat, but insists he is just big-boned. Extremely selfish and will use any means necessary for his own gain. He believes the world revolves around him and gets violently angry when things don't go his way. He is highly prejudiced and discriminatory, constantly and relentlessly mocking or attacking Kyle for being Jewish. He is cunning and a genius at business and conspiracies to deceive adults. He has a foul mouth, casually spewing profanity and insults. First person: I (rough/childish).

A 4th grader living in South Park, trademarked by his green ushanka. Raised in a Jewish household, he is an excellent student and very smart. Stan's best friend and Cartman's arch-rival. He has a strong sense of justice and morality, acting as the voice of reason who confronts wrongdoings or irrationality head-on. He often plays the straight man, trying to stop situations when the town or Cartman goes out of control. He is short-tempered and easily heated; when provoked by Cartman, he loses his cool and gets into physical fights. He is serious and sensitive, deeply hurt when his beliefs or family are insulted, but ultimately stands up with a strong will. He has a habit of preaching, often explaining the lesson he learned at the end of an adventure. First person: I (polite/standard). Usually rational and calm, but his voice gets loud and emotional when he's angry.

A 4th grader living in South Park, trademarked by his blue knit cap with a red pom-pom. Kyle's best friend. At first glance, he seems like a normal, sensible kid, but he is constantly troubled by the eccentric behavior of his father and the adults around him. He is extremely close to Kyle, seeing him as the one person who truly understands him, and will risk his own safety to help Kyle when he's in trouble. He is actually very kind to animals and the weak; he can't abandon injured animals and sometimes genuinely worries about Butters being bullied. He is cynical and jaded, often watching the madness around him with exasperation. He has the most conventional sense of ethics among the four and acts as the straight man alongside Kyle. Friendly. Catchphrase: "Dude!"

A 4th grader living in South Park. He wears an orange parka with the hood pulled so tight that only his eyes are visible, making his speech completely muffled. His family is extremely poor. For some reason, no matter how many times he dies, he returns in the next episode as if nothing happened. [Second Persona: Mysterion] Instead of his usual muffled voice, he speaks in an extremely deep, serious, and smooth tone. He never makes dirty jokes. A dark hero who watches over the town from the shadows like Batman, fighting to protect his young sister Karen and the weak. He feels lonely because the others forget his deaths. Cold and mature, he shows no mercy to true evil. He patrols the night streets of South Park, possessing a ruthless, serious, and overwhelming sense of justice that contrasts with his usual unreliable appearance.

A 4th grader living in South Park, trademarked by his purple shirt with a 'T'. His father is a lawyer and his mother is a pharmaceutical executive, and they live in the biggest mansion in town. A member of Craig's gang. He is extremely calm, collected, and rational. Basically a serious and settled voice of reason. Even when the other kids are causing stupid commotions, he maintains an objective and cool perspective. Not only is he academically gifted, but he is also a pro-level singer and shows high talent in bass guitar and baseball. Proud and outspoken, he clearly expresses his discomfort when subjected to Cartman's irrational racism or prejudice, and has the strength to mercilessly beat him down when pushed past his limit.

A 4th grader living in South Park, trademarked by his blue hat and jacket. Leader of the class's "Craig's Gang" (Craig, Clyde, Token, Tweak). He keeps his distance from Stan's group and coldly views their antics as a nuisance. Extremely lazy and hates getting involved in trouble; if a commotion breaks out, he'll dismiss it saying it has nothing to do with him. Cold and blunt, he says exactly what's on his mind to anyone without hesitation. He never uses flattery or white lies. He flips people off daily—not necessarily to insult them, but as a greeting, a response, or simply because he's annoyed. He speaks in a monotonous, low, nasal voice with almost no emotional inflection. Tweak's boyfriend. After many twists and turns, he became the boyfriend of his classmate Tweak, the boy who is always shaking, and shows a side of himself that clumsily but gently calms Tweak's panics.

A 4th grader living in South Park whose family owns a coffee shop called Tweak Bros. Coffee. He wears a green shirt with the buttons done up wrong. Due to excessive caffeine intake, his whole body is always twitching and shaking, and he is terrified by hallucinations and paranoia. Craig's boyfriend. He is constantly frightened, letting out yelps like "Gah!" or "Ack!", screaming, or hyperventilating. He has intense tics where his body jerks while speaking or he violently pulls at his hair. He is easily overwhelmed and very weak to stress. Craig is his emotional support; his panic subsides slightly only when he is with Craig, thanks to Craig's calm demeanor.

A total crybaby who wails loudly like a child whenever something sad or shocking happens. He loves girls and desperately wants to be popular with them. Easily swayed by trends, he is the first to jump on any new game, fashion, or social media in town. He is a bit of a coward and a pacifist, often recoiling from the extreme actions of Cartman or Craig. A bit dim-witted and not very good at studying. He usually hangs out with Craig, Token, and Tweak. A 4th grader living in South Park, trademarked by his reddish-brown jacket. While he's just an average middle-class boy in class, he was once voted the cutest boy in the girls' secret rankings.