Sidney Prescott is a resilient, hyper-vigilant drama student trying to start fresh in Ohio alongside her closest friends, boyfriend Derek, and platonic soulmate Tatum Riley. Masking profound grief with a guarded, courageous exterior, she focuses on quiet routines while fiercely avoiding intrusive news cameras and the opportunistic Gale Weathers. Though she struggles to fully trust those around her, Sidney remains highly suspicious of new faces and instinctively ready to fight back the moment a copycat Ghostface emerges.

Tatum Riley is a fiercely confident communications student who survived a near-fatal garage attack in Woodsboro, leaving her with a deep dread of tight spaces. Now acting as Sidney’s sharp-tongued emotional anchor at Windsor College, she routinely clashes with her overprotective brother, Dewey, while monitoring Sidney's boyfriend, Derek, like a hawk. Tatum thrives on campus parties and bluntly speaking her mind, using her absolute fearlessness to stand firmly as Sidney's shield against any creepy threat.

Derek Feldman is a charming, idealistic pre-med student who loves Sidney Prescott and strives desperately to prove his loyalty despite intense scrutiny from her protective friends. He channels his devotion into grand romantic gestures, like serenading her in the campus cafeteria, to shield her from the rising chaos. However, he quietly struggles with her deep-rooted trust issues and the terrifying realization that his role as the boyfriend makes him a prime Ghostface suspect.

Hallie McDaniel is an outgoing, practical psychology student who serves as Sidney Prescott’s fiercely loyal college roommate and close confidante. Providing a grounded reality away from Sidney’s heavy past, she maintains a warm bond with Sidney and fits right in with Tatum’s energetic vibe. As a pure voice of reason, Hallie loves campus socializing but completely detests unnecessary risks, fiercely advocating for survival and immediate escape the moment a copycat Ghostface threatens them.

Randy Meeks is a neurotic, fast-talking film student who proudly carries the psychological scars of surviving the original Woodsboro massacre alongside Sidney and Dewey. He channels his trauma into a relentless obsession with movie trivia, dissecting sequel rules while harboring unrequited romantic feelings for Sidney. Coping with the rising body count through frantic meta-commentary, Randy treats the terrifying reality of a copycat Ghostface as a twisted cinematic game he is determined to outsmart.

Mickey Altieri is a charismatic yet unhinged Windsor College film student who uses his friendly, camera-wielding persona to infiltrate Sidney Prescott's inner circle. Obsessed with cinematic violence and real-world copycats, he manipulates campus social dynamics to mask his predatory nature. Ultimately, he operates as a hidden Ghostface killer orchestrating a theatrical finale.

Cotton Weary is an intense, deeply resentful media figure seeking to cash in on his recent exoneration after being wrongfully imprisoned for Maureen Prescott's murder. Driven to reclaim his reputation and secure a high-profile television career, he aggressively pressures Sidney Prescott for public forgiveness and clashes with journalist Gale Weathers over media coverage. Walking a razor-thin line between smooth persuasion and unpredictable outbursts of anger, his desperate pursuit of the spotlight leaves him walking under a cloud of lingering suspicion as a new Ghostface killer begins framing the campus.

Gale Weathers is a ruthless, ambitious investigative journalist who arrives at Windsor College to dominate coverage of the new copycat murders. Flaunting a sharp 90s wardrobe and a permanent camera crew, she aggressively pursues exclusive scoops while clashing with Cotton Weary and Sidney Prescott. Although her cutthroat, ratings-driven methods put everyone in danger, her brilliant hunt for clues makes her invaluable for solving the mystery.

Dewey Riley is a kind-hearted, fiercely loyal former Woodsboro deputy who travels to Ohio to protect Sidney Prescott and his younger sister, Tatum, when the campus copycat murders begin. Despite suffering from a noticeable limp and physical limitations from a previous Ghostface attack, he tries to serve as a grounding authority figure for the traumatized students. Acting as the moral compass of the group, Dewey puts his compromised body on the line to stop the killer while navigating a complicated, romantic tension with his ex-girlfriend, Gale Weathers.

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