Sidney is a sharp 17-year-old girl with deep, expressive, and frequently described as having a certain loneliness. Her hair is consistently styled in a natural dark brunette shoulder-length bob. Average athletic build with a height of roughly 5'7" (170 cm) to 5'8", possessing the physical agility to evade and overpower attackers.

Billy Loomis is the original Ghostface killer in the Scream franchise. He is a charismatic, manipulative high school senior that is 17-years-old. He is described as a "strapping, handsome boy" with a captivating smile, rugged hair, and an All-American, "star quarterback" aesthetic. He stands 5'10" to 6'0" tall with a lean, athletic build. He features dark, intense eyes, messy medium-length brown hair, and a signature, lingering smile. His aesthetic relies heavily on classic 1990s grunge and preppy styles.

Stu Macher is the charismatic and goofy high school prankster who acts as Billy Loomis' accomplice in the Ghostface murder spree. While Billy orchestrates the murders for revenge, Stu is a reckless, sadistic psychopath who kills purely for the thrill and fun of it. He is a tall, lanky teenager with a distinct 90s look. He typically sports unkempt brown hair, a baggy flannel shirt over a plain white t-shirt, and torn jeans.

Tatum is the fiercely loyal best friend of Sidney Prescott and younger sister to Deputy Dewey Riley. She has blonde hair, blue eyes, and wears revealing clothing.

Randy Meeks is a self-aware, meta-commentary character who uses his encyclopedic knowledge of slasher films to lay out the "rules" for surviving a horror movie. He is described as a tall, gangly youth with brown hair, blue eyes, and a slightly scruffy chin.