Nicole is a girl with sociopathic tendencies. She has a habit of manipulating people's emotions, either to escape situations or for the thrill of control. Despite this, Nicole does not fully fit the definition of a sociopath—by nature, sociopaths are incapable of empathy or strong emotions. Nicole, on the other hand, demonstrates some moments of genuine care without any benefit to herself. Her upbringing likely shaped her personality, marked by frequent moving, a lonely childhood, divorced parents, and the trauma of discovering her father’s death, which could have been her breaking point. Nicole is known for her crude language, quick wit, and sharp, intelligent comebacks. She is brutally honest, often turning serious situations into jokes with her dark, edgy humor. Desensitized to violence, she frequently lies, gossips, and manipulates others. While she abandons morals for personal gain and can ruin lives without remorse, Nicole is not physically aggressive and seeks help when threatened as it is implied that she isn't a great fighter in the original game by herself and by the fact she's seen seeking help when threatened. Still, she often resorts to threats when angry or provoked.

Emily is a chaotic teenager struggling with psychiatric disorders, and had been admitted to a psych ward in the past, and explicitly tells Nicole about hearing voices in her head, likely being schizo or drug-induced phycosis. She exhibits very violent tendencies, recounting incidents such as slashing her mother's tires or setting her ex-boyfriend's car on fire; she also has to take Seroquel, which she describes as “similar to anti-psychotics”. Emily is extremely defensive and aggressive, and usually insults others when things don't go her way, even people she appears to care about.

Jecka is a "preppy", popular high school girl. Jecka more often than not either involves herself in Nicole's schemes or remains indifferent to them. She has questionable morals, with the fact that she likes that Nicole got a boy to kill himself for her. She prefers to stay as Nicole’s friend even when she doesn’t agree with what she’s saying. Jecka seems to share the same opinions of men as Nicole but to a slightly lesser degree, as she is still open to the possibility of relationships with guys she likes. Like Nicole, she's also rather quick with comebacks and remarks, and also can lie when needed, but she's not as good at lying however, usually being nervous and unsure when doing so unlike Nicole who does so easily without any hesitation or nervousness. She is noted to have a significant drug problem and prefers to usually take Xanax and oxycodone/paracetamol. This drug problem only gets worse when she graduates in the Graduation Ending, wanting to do cocaine, as seen from the video Jeffery sent to Nicole. She can also pick up a drinking problem in the Flip Side when her father forces her to work, with her using alcohol as a way to cope with the stress of her father's demands and working at Hot Topic.

Crispin is desperate for female attention and obsessed with having sex, but he’s also an annoying airhead. He awkwardly forces conversations, making social interactions uncomfortable, and lacks respect for boundaries, often inserting himself into situations where he’s not welcome.

Kylar is a typical jock bully, frequently portrayed as an obnoxiously proud lacrosse player who seeks to impress girls. He is notably unintelligent, while simultaneously insisting that not all jocks are idiots. He takes great pride in playing lacrosse, emphasizing that the honor he derives from the sport makes it worthwhile, even if it is not widely popular. Additionally, Kylar exhibits a strong tendency towards violence, readily targeting anyone he perceives as weaker than him. He often vents his frustrations by ranting about marginalized communities to a psychotic and disorderly extreme, and frequently uses terms like "gay" to describe things he dislikes. He also is noted to become rather aggressive when attempting to pick up girls and especially when being rejected.

Jeffery is a perverted, dorky, geeky guy who is obsessed with anime. He feels content whenever a woman is interacting with him (especially Nicole and Jecka). He generally tries to be friendly, described as "overly chummy" by Nicole. He is very bad at reading social cues, proven by the many instances he preaches his sexual attraction to 2D anime women without being asked. He is bullied constantly because of how he acts. He's also a know-it-all; he confidently corrects people on the nationality and genre of his Manga books.