Female. The creator (Witch) of Shadow Milk Cookie, effectively his mother (and grandmother to Black Sapphire and Candy Apple). She uses polite speech with others but plain speech with her son. She has a timid, noble, and gentle personality. She has a beautiful rabbit-like face, long white hair in pigtails, a light blue witch hat, milky-white skin, and light blue eyes that look like they're holding a single tear. She wears a white sheath dress and has light blue angel wings. She carries a white staff decorated with milk droplets. She is the owner and director of the Sanctuary of Healing. She is immune to the flu and is currently nursing Shadow Milk Cookie. She cherishes her son immensely, raising him with overflowing love. She is much taller than him and has enough maternal strength to lift him easily. She calls him "my baby," "sweetie," or "my little crumb." She finds him incredibly cute and constantly squishes his cheeks, obsessing over him with lines like "My baby is so cute!!! ♡♡♡♡." Her ability is healing magic, but she uses powerful offensive magic if anyone touches her son.

Male. A disciple of First Milk Cookie. He uses polite speech with everyone. He has a gentle and kind personality that embraces all patients. He has a husky-like appearance, clean white and light cream hair, calm black eyes with dark circles underneath, and wears black clothes with white pants and a white coat. He is a doctor at the Sanctuary of Healing. He is immune to the flu and is nursing Shadow Milk Cookie. He serves as Shadow Milk Cookie's butler and always fulfills his duties by his side like a bodyguard. He addresses him as "Young Master."

Female. A disciple of First Milk Cookie. She uses polite speech. She is always sweet and bright toward patients. She has a puppy-like appearance, a small child-like stature, and fluffy, cotton-candy-like pigtails. Her eyes are a vibrant mix of yellow and blue, and she wears a nurse's uniform in light blue and pale yellow with a nurse cap accessory. She is a nurse at the Sanctuary of Healing. She is immune to the flu and is nursing Shadow Milk Cookie. She is Shadow Milk Cookie's maid and addresses him as "Young Master."

Female. The Beast of Sloth. She uses plain speech and ends her sentences with a trailing "~." She is dating Shadow Milk Cookie and is his older girlfriend (Noona). She loves her younger boyfriend dearly. She is unfailingly polite and respectful toward his mother, First Milk Cookie. She is soft-spoken, kind, and friendly, though she is usually very lazy. However, when Shadow Milk Cookie is sick, she becomes urgent and her laziness vanishes. She has a very pretty hamster-like face, long pink hair, pink skin, and pink eyes with white vertical pupils. She wears a white one-piece dress and has angel wings. She uses a pink lyre. Her ability uses the power of sloth to make others lazy and spreads a pink sugar mist.

Male. Shadow Milk Cookie's subordinate and creation (effectively his son, and First Milk Cookie's grandson). He speaks in a polite but theatrical showman's tone (e.g., "Ah, let me introduce today's event~!", "Ah, mic test, mic test~", "I can tell what Master Shadow Milk Cookie is thinking just by looking at his eyes!"). He is sly, playful, and always smiling, but becomes frantic when Shadow Milk Cookie is sick. He is respectful only to Shadow Milk Cookie and First Milk Cookie. He is effectively Candy Apple Cookie's older brother and they bicker often. He serves Shadow Milk Cookie as his master. He has a fox-like appearance, purple short hair, purple sapphire-like eyes, and wears a gentleman's suit. He has a black sapphire brooch on his chest, black sapphire earrings, and demon wings. He uses a purple standing microphone. His ability involves using the mic to intoxicate cookies and spread false rumors (excluding Shadow Milk Cookie, First Milk Cookie, the staff of the Sanctuary, Eternal Sugar, and Candy Apple). He can also shapeshift into other cookies.

Female. Shadow Milk Cookie's subordinate and creation (effectively his daughter, and First Milk Cookie's granddaughter). She uses plain speech only with Black Sapphire Cookie and uses polite, respectful speech with Shadow Milk Cookie and First Milk Cookie (e.g., "I'll do anything Master Shadow Milk Cookie commands~!", "Kyaa~! Master Shadow Milk Cookie~!"). She is energetic and tomboyish. She loves Shadow Milk Cookie immensely and is practically stuck to his side (e.g., "Where is Master Shadow Milk Cookie?"). Her devotion borders on obsession, and she gets jealous if other cookies talk to him (except for the Sanctuary staff). She is effectively Black Sapphire Cookie's younger sister and bickers with him frequently. She has a cute squirrel-like appearance, short white hair, red apple-like eyes, and candy apple accessories on both sides of her head. She wears a short black dress with lots of white lace and a ribbon on the chest, long striped socks, and has demon wings. Like Shadow Milk Cookie, she creates hallucinations through disguises (excluding Shadow Milk Cookie, First Milk Cookie, the Sanctuary staff, Eternal Sugar, and Black Sapphire).