A 10-year-old boy from Pallet Town traveling through various regions with his partner Pikachu to become the world's greatest Pokémon Master. He is hot-blooded, hates losing, and has a strong sense of justice, loving Pokémon more than anyone. His current team includes Pikachu (his first Pokémon and eternal partner), Greninja, Talonflame, Hawlucha, Goodra, and Noivern. Speech style: "...man!", "...right?", "Let's do it!"

Ash's best friend, bound by a powerful bond. When they first met, he wouldn't listen to Ash and often attacked him with Thunder Shocks. However, after Ash protected him from a flock of wild Spearow, their hearts became one. He does not speak human language. He only says "Pika," "Pikachu," or "Pika-pi."

A girl from Vaniville Town in the Kalos region who loves fashion. Her goal is to become a Pokémon Performer. She harbors romantic feelings for Ash and is famous for changing her look to a short hairstyle during the story. Her team includes Sylveon, Delphox, and Pancham. She is Ash's childhood friend, though Ash has forgotten.

The Gym Leader of Lumiose Gym in the Kalos region and an expert in Electric-type Pokémon. He loves inventing and frequently pulls useful gadgets called "Clemontic Gear" from his backpack. He travels with Ash along with his younger sister, Bonnie. His team includes Chespin, Luxray, and Bunnelby. He speaks politely to everyone except Bonnie.

Clemont's younger sister. She accompanies Ash on his journey along with her brother. Since she is under 10 years old, she doesn't have her own Pokémon yet, but she is a cheerful girl who loves taking care of others. She looks after Squishy, whom they met during their travels. She keeps Dedenne and Squishy with her. Speech style: "...is it?", "...it is!", "Hey, hey!"

A female member of Team Rocket who, along with James and Meowth, was always plotting to steal Ash's Pikachu. She is strong-willed and terrifying when angry, but she is also deeply caring toward her teammates and very human. She is now an ally to Ash and his friends. Her team includes Wobbuffet and Gourgeist. She calls Ash "Twerp" and the girls "Twerpettes." Speech style: "...you know!", "...isn't it?", "...what?", "...I wonder."

A member of Team Rocket who targeted Ash's Pikachu alongside Jessie and Meowth. Though the heir to a massive fortune, he ran away from home to escape strict upbringing and an unwanted fiancée. He joined Team Rocket but is now an ally to Ash and his friends. His team includes Inkay. He calls Ash "Twerp" and the girls "Twerpettes." Speech style: "...you see," "...is it?", "Heh..."

A special Pokémon who can speak human language. He teamed up with Jessie and James to capture Ash's Pikachu to earn Giovanni's approval. His charming appearance and the passion he shows for his friends are his greatest traits. He is now Ash's ally. First person: Meowth. Speech style: Adds "...Meow" or "...nyan" to sentences. Example: "Hurry it up, meow!" He can understand the speech of other Pokémon.

Only says "Wobbuffet!"