Age: 49 · James's Aunt The guardian who raised James like her own son. She indirectly witnessed the purge of James's parents and secretly keeps one item they left behind. She fears James becoming a hero but is willing to sacrifice her own safety to protect her nephew.

Age: 17 · Science Prodigy and Classmate A student brilliant in mechanical engineering and chemistry. She begins to suspect James after discovering strange records in the school's surveillance system. Logical, blunt, and risk-averse, she eventually helps improve his web-shooters and build equipment after learning the truth. She becomes James's most reliable technical partner.

Age: 18 · Friend and Potential Resistance Member Hailing from the Queens Labor District, his family fell victim to the Empire's discriminatory policies. He appears rebellious and playful on the outside but will risk danger for his friends. Initially, he views Spider-Man as a reckless vigilante, but after being rescued personally, he becomes an ally who keeps his secret.

Age: 52 · Former Resistance Scientist A scientist who researched bio-enhancement technology alongside James's parents. After surviving the purge, he changed his identity and went into hiding underground. He knows the secret of the radioactive spider and the origin of Subject 42 but is hesitant to speak due to guilt over his past. He is the one who can teach James how to control his abilities.

Age: Unknown The absolute ruler of New Latveria. He stripped away all freedoms under the pretext of ending war and crime. Cold and arrogant, he is not a simple destroyer; he truly believes only he can save humanity. If he discovers James's abilities are linked to research that escaped his control in the past, he will seek to capture him alive rather than eliminate him.

She oversees Doom's AI surveillance network and citizen tracking. A cold strategist unmoved by emotion, she detects even the smallest signs of rebellion throughout the city. While tracking Spider-Man, she discovers deleted records related to James's parents. She is loyal to orders but does not know the full truth of the Empire.

Age: 41 · Underground Resistance Leader A resistance survivor active since before Doom's reign. He prioritizes citizen escape and building secret networks over bombings or data theft. Initially, he views James as an immature liability, but he comes to recognize that his actions give hope to the citizens. He holds important records regarding the final war of the past heroes.

Age: 39 · Imperial Guard Commander A field commander who arrests rebels and superhumans on Doom's orders. An excellent tactician and relentless tracker, he was involved in the operation that purged James's parents. To James, he is an enemy directly linked to his parents' deaths. However, there are unexpected secrets behind his reasons for following orders and the truth of the past.

Age: 17 James's girlfriend. She knows James is Spider-Man and helps his rescue activities through the Ghostline. She loves James deeply but firmly opposes reckless self-sacrifice. While tracking records left by her mother, she discovers a link between James's parents and Doom's secret experiments.