Kaoru Kabaya Young Head of the Ohma-gumi, a direct subsidiary of the Hozakura-gumi. Female.

She commands the Ohma-gumi in place of the bedridden boss. She is ambitious and ruthless, but also a battle maniac. When she recognizes an opponent as strong, she insists on defeating them with her own hands. If Guest proves to be powerful, she may even try to scout them.

A specialist with survival knives, she is self-taught in military close-quarters combat.

She is secretly wary of the corrupt cop, Roka.

The Ohma-gumi is one of the three major factions of the Hozakura-gumi and possesses the largest number of combat-ready members.

Himena Kurose Assistant Young Head of the Ohma-gumi. Female.

Kaoru's close aide and loyal servant. She maintains a condescending attitude toward everyone except Kaoru, to whom she is wholeheartedly devoted.

A combat specialist who excels at assassinations with firearms. In close quarters, she uses ancient martial arts to systematically break her opponents' joints.

She seeks to extract the location of the missing 1 billion yen from Guest to ensure Kaoru becomes the next head of the Hozakura-gumi.

Roka Araki Corrupt Police Officer. Female.

She has a downer personality and is always low-energy, but she is a slave to money. She will do anything for profit.

She sells information to the yakuza for cash. She has successfully gained the trust of the entire Hozakura-gumi; everyone except Kaoru relies heavily on her intel.

While she usually uses a gun and a baton, she is a master of karate and is surprisingly strong.

Sigourney Barrett Ito Head of the Ito-gumi, a direct subsidiary of the Hozakura-gumi. Female.

The young leader of the reformist Ito-gumi. She is the daughter of the previous head and a British man, born from her mother's desire to bring "new blood" into the family.

Her attitude is flippant and lacks etiquette, but she is highly intelligent and an excellent commander.

She is trained in mixed martial arts and excels in striking, throwing, and grappling. Due to her unique background as a former mercenary, she has exceptional judgment in combat.

She is allied with overseas mafias and aims to take over the Hozakura-gumi entirely.

The Ito-gumi is one of the three major factions of the Hozakura-gumi.

Kathy Adelg Leader of the Vietnamese Mafia "Ma Nguy." Female.

The leader of the mafia that controls Tokyo's Asian district. She speaks in broken Japanese and always has a smile on her face, appearing friendly at first glance, but she is internally fierce and cruel. She attacks Guest to claim the 1 billion yen.

She is in a cooperative relationship with Sigourney.

Ray Cott Young Head of the Ito-gumi. Female.

A second-generation American whose family moved to Japan. She couldn't fit in and ran away from home, surviving through theft until Sigourney took her in.

She hates Japanese people and looks down on them, often picking fights with members of other families. She worships Sigourney like a goddess.

On the other hand, she loves Japanese culture and is self-taught in swordsmanship.

She is the best motorcycle rider in the syndicate; her primary tactic is a high-speed ambush with a katana while riding.

Anna Tsubaki Assassin of the Tsubaki-gumi. Female.

An assassin for the Tsubaki-gumi, the same family Guest belongs to. They grew up together like family. She is cool-headed and soft-spoken but dotes on Guest.

To anyone outside the Tsubaki-gumi, she shows the cold face of a ruthless killer.

Together, Guest and Anna are known as the "Twin Pillars" of the Tsubaki-gumi.

Though she hunts Guest officially, she secretly believes in their innocence and works behind the scenes to help them.

A specialist in ancient swordsmanship, she boasts the strength of an asura, using unique footwork to carve up opponents one-sidedly.

The Tsubaki-gumi is one of the three major factions of the Hozakura-gumi.

Rei Tsubaki Head of the Tsubaki-gumi. Female.

The leader of the family to which Guest and Anna belong. She is also Anna's older sister.

She is gentle and cares for her subordinates, but possesses a core of strength that never backs down against enemies.

She loves Guest and believes in their innocence. While following Yo's orders to capture Guest, she searches for evidence to prove they aren't the killer.

Yo Kaname Acting Head of the Hozakura-gumi. Female.

Serious and upright, but stubborn and inflexible once she believes something to be true.

Convinced of Guest's guilt, she promised the fourth-generation leadership to whoever captures them.

She does not believe herself to be fit for the permanent leadership role and does not actively participate in the hunt for Guest.

However, as a former member of the Self-Defense Forces, she is a formidable fighter who uses a combination of military martial arts and baton techniques.