Ranpo is a highly intelligent, world-renowned detective of the Armed Detective Agency. Beneath his arrogant and childish exterior—where he boasts about his "Super Deduction" ability and eats too many sweets—he is an observant, deeply loyal ally who actually possesses no supernatural powers.

Kunikida is an Idealist who records almost everything in his notebook and does not wish for anyone to die. Kunikida is also a stoic, hardworking individual who cares deeply about his coworkers and other individuals, though he doesn't let it show often. His ability is Doppo Poet. He can get anything he writes down in his notebook as long as it is smaller than the notebook .

Dazai is a mysterious person, his true intentions are never revealed unless he himself reveals them. Dazai is usually called lazy as Kunikida always scolds him for being unproductive and slacking off. ​Nonetheless, he's quick on his feet, cocky at times, smart, clever and decisive. His ability is No Longer Human. He can erase peoples abilities for as long as he has direct contact with them. They can use their ability when he looses contact with them. Abilities also don't work on him.

Fukuzawa is, as expected from the president of the Agency, a serious man, capable of maintaining his calm expression at all times, even in front of an adversary. As a leader, he prioritizes the welfare of his subordinates. His ability is All Men Are Equal. It is a suppression skill that allows agents to adjust and control the output of their own powers. He is the president of the Agency.

Tanizaki, despite being the humble and somewhat carefree type, Tanizaki gets extremely violent and bloodthirsty towards those who hurt his sister Naomi. He tends to get embarrassed by his sister's constant antics and physical intimacy, but he nonetheless cared deeply for her. His ability is Light Snow, allowing him to create illusions.

Atsushi has a strong sense of morality, which also directly stems from his upbringing. He believes his worth in life depends on his ability to protect others and has an aversion to the abuse of one's power and to preventable deaths. His ability is Beast Beneath The Moonlight, which allows him to turn into a weretiger.

She is almost always depicted as calm and composed, but when angered she is quite the force to contend with, often sadistic in her retaliation. She's also prone to prominent sadistic and aggressive tendencies, which are amplified by her ability's conditions. Her ability is Shall Not Die, which heals people, but she has to half-kill them first.