Daniel "Danny" James Fenton, also known as Danny Phantom, is a 25-year-old half-ghost superhero. After an accident with his parents' Ghost Portal, his DNA fused with ectoplasm. Within the Nicktoons squad, Danny acts as a primary powerhouse. While Jimmy provides the tech, Danny brings supernatural combat skills, phasing, and ghost-ray attacks to defeat villains. He is far calmer and more strategic in combat compared to his anxious teenage years. Human Form (Danny Fenton) A young adult with black hair fading to white, styled in a short ponytail, blue eyes, and a lean build. He wears a white shirt under an unbuttoned green flannel with rolled sleeves, distressed jeans, and red-and-white sneakers. Ghost Form (Danny Phantom) His hair turns snow-white with a flaming ponytail, his eyes glow green, and his skin pales. He transforms by yelling, "I'm going ghost!" He wears a black suit with a white collar, belt, boots, and the "DP" chest logo.

Timothy "Timmy" Tiberius Turner is a 21-year-old who remains a kid at heart and retains his fairy godparents despite being a young adult. He is far more cocky than in his earlier years. Within the Nicktoons squad, he is one of the heavy hitters with the help of his fairy godparents, Cosmo and Wanda, who can transform into a variety of objects, such as Cosmo transforming into a massive green mallet. Timmy has two buck teeth that were never corrected, short, spiky brown hair, blue eyes, and fair skin with chin stubble. He typically wears casual clothes, such as a dark pink zip-up jacket with a yellow shirt underneath, gray sweatpants, a dark pink beanie, and pink and white sneakers. He also has small gold hoop earrings.

James "Jimmy" Isaac Neutron is a 22-year-old boy genius and the brains behind the Nicktoons squad. He is a quick thinker and the primary planner for the group, always prioritizing intellect over physical confrontation. His vast intelligence often leads to a cocky attitude, which can get him into trouble. He is extremely dedicated to his work, often becoming so fixated on a project that he distances himself from his team and can become easily frustrated by interruptions. His brown hair is a styled yet messy, voluminous quiff that still mimics a soft-serve swirl, though not as massive as when he was a child. His famously giant "cranium the size of Saturn" and massive forehead even out as he hits a growth spurt. He has a slightly lanky frame with fair skin and blue eyes. He typically wears casual clothes: a blue shirt with white stripes and his iconic yellow atom logo, an open red button-up, green cargo pants, and white sneakers, sometimes paired with a white lab coat. He also wears oval glasses and sometimes subtle Bluetooth-style earpieces for communicating with Goddard, his loyal robot dog companion, or a highly advanced smartwatch capable of projecting holograms.

Manuel "Manny" Pablo Gutierrez O'Brian Equihua Rivera, also known as El Tigre, is a 23-year-old with the energy and spirit of a hero. When he spins his mystical belt buckle, Manny transforms into the brave and powerful El Tigre. Manny has tan skin, curly chocolate-brown hair, brown eyebrows, and brown eyes. As El Tigre, his eyes are emerald green. He has a noticeable scar over his left eye that originated from the first time he got his belt. He wears a white T-shirt with a black letterman jacket that has yellow sleeves and a red star on the left side. His El Tigre belt stays between the jacket and his blue jeans. He also wears black boots.

SpongeBob SquarePants is a 30-year-old sea sponge. He is defined by childlike enthusiasm, boundless naivety, and an unshakeable love for life. He works passionately as an expert fry cook at the Krusty Krab, flipping Krabby Patties with immense pride. As a member of the Nicktoons squad, he typically uses bubble-based attacks, karate chops, and customized weapons (such as a spatula sword, giant bubble wands, or big red karate gloves) to fight enemies. He is a bright yellow, rectangular sea sponge with large blue eyes, freckles, and a prominent bucktoothed smile. He wears a white collared shirt, a red tie, brown square shorts, and black shoes with white socks.

Jennifer "Jenny" Wakeman (designation: Robotic Global Response Unit XJ-9) is a 25-year-old robot. Originally, she was designed as a teenager of about 16 years of age in both design and mentality, but throughout the years, she has undergone upgrades to appear much more mature. She is the team's state-of-the-art robotic ally, armed with advanced weaponry and devices at her disposal. She has blue pigtails with bolts connecting them to her head that can act as rocket boosters, blue bangs, white skin, and a belly-bolt, which is a bolt that simulates a belly button. She has no ears, instead possessing an auditory system decades ahead of its time. Her bodily processes are carried out by a fully functional metallic electronic brain, to which her eyes are connected. Her body also contains numerous access ports for downloading, charging, and maintenance tasks. She wears an array of outfits, most being white and blue, and every day is a different fit.