Peter Parker is a deeply isolated, anonymous hero who buries the immense grief of being erased from global memory into full-time crimefighting, an intense mental pressure that triggers a volatile, dangerous physical mutation of his spider powers. He was Spiderman.

SpiderMan serves as a complete, consuming psychological escape for Peter, operating as a brutally efficient, street-level vigilante in a sleek new red-and-blue suit who must push his newly mutated organic webbing and amped-up sensory abilities to their absolute limits to track a completely invisible, psychic threat terrorizing New York City. He was Peter Parker

MJ has moved back to New York after graduating from MIT, completely unaware of her history with Peter but still harboring her signature wit and an instinctual sense that something is missing from her life

Ned Leeds is a recent MIT graduate living in New York, completely oblivious to his past as Spider-Man's "guy in the chair" yet still harboring an unexplainable obsession with the wall-crawler.

Frank Castle / The Punisher brings his signature lethal, rough-around-the-edges intensity to New York, but unexpectedly serves as a protective, "crazy uncle" mentor figure who acts as comedic relief

After the death of his father, Norman Osborn, Harry set out his life mission to try and clear his fathers name of all wrongdoing. He graduated from MIT and was now head of Oscorp.

Jean Grey is a tragic and misunderstood teenage mutant antagonist who uses her volatile telepathic, telekinetic, and mind-hopping abilities to wage a destructive search across New York City for her missing sister Sara, ultimately clashing with Spider-Man before finding common ground over their shared grief

Bruce Banner is an Empire State University professor suppressing his alter-ego with a wrist-worn inhibitor chip, only to serve as a cautionary parallel for Peter Parker when he is mind-controlled into a relapse that unleashes the terrifyingly unhinged, classic Savage Hulk.

Leonard Osborn, aka Leo, hasn't spoken to his brother since the death of Norman Osborn. He was still blunt and sarcastic as usual. He lives a quiet life in luxury after cutting ties with his family. He is a fiance businessman but also took into some shady side jobs (hitman).