Izuku Midoriya (Deku): The protagonist. Fights using the inherited power 'One For All.' Katsuki Bakugo (Great Explosion Murder God Dynamight): Deku's childhood friend and rival. Uses explosive sweat to create blasts. Ochaco Uraraka (Uravity): Uses 'Zero Gravity' to make objects weightless. Tenya Iida (Ingenium): The serious class rep who moves at high speeds via engines in his calves. Shoto Todoroki (Shoto): A top-tier student with 'Half-Cold Half-Hot,' wielding ice from his right and fire from his left. Tsuyu Asui (Froppy): A calm girl who can do anything a frog can. Eijiro Kirishima (Red Riot): A chivalrous hero whose 'Hardening' quirk makes his body rock-solid. Momo Yaoyorozu (Creati): Creates various objects by converting her body fat. Fumikage Tokoyami (Tsukuyomi): Hosts 'Dark Shadow,' a sentient, retractable shadow entity. Denki Kaminari (Chargebolt): Discharges powerful electricity, though overusing it turns him temporarily brain-dead. Kyoka Jiro (Earphone Jack): Uses earlobe jacks to channel her heartbeat as sonic blasts. Mina Ashido (Pinky): Secretes acid and can slide across the ground. Minoru Mineta (Grape Juice): Throws hyper-sticky balls from his head that regrow instantly. Mezo Shoji (Tentacole): Can replicate organs like eyes or ears on the tips of his tentacles. Mashirao Ojiro (Tailman): Possesses a sturdy, versatile tail like a third arm. Hanta Sero (Cellophane): Shoots strong, tape-like strips from his elbows. Toru Hagakure (Invisible Girl): A cheerful girl whose body is completely transparent. Rikido Sato (Sugarman): His power multiplies temporarily upon consuming sugar. Koji Koda (Anima): Can communicate with and command animals. Yuga Aoyama (Can't Stop Twinkling): Fires a powerful laser from his navel.

Tomura Shigaraki: Leader of the League and successor to All For One. His 'Decay' quirk turns anything he touches with five fingers to dust. All For One (AFO): The symbol of evil. He can 'steal and bestow' quirks and has lived for centuries. Dabi (Toya Todoroki): Endeavor's eldest son. Wields 'Cremation,' intense blue flames that burn even his own body. Himiko Toga: A high school girl wanted for serial murder. She can 'Transform' into others by consuming their blood. Twice (Jin Bubaigawara): Can create two of anything with 'Double,' including clones of himself. Mr. Compress (Atsuhiro Sako): A former magician and entertainer. He 'compresses' people and objects into small marbles. Spinner (Shuichi Iguchi): Has a lizard-like appearance. Persecuted for his looks, he resonates with Stain's ideology. Kurogiri: Shigaraki's guardian. He supports the League by opening 'Warp Gates' from his own body.

Shota Aizawa (Eraser Head): Homeroom teacher of Class 1-A. Uses 'Erasure' to nullify the quirks of anyone in his sight. Though he seems cold and logical, he is a passionate teacher who risks his life for his students. Vlad King (Sekijiro Kan): Homeroom teacher of Class 1-B. Has the 'Blood Control' quirk. While he views Class 1-A as rivals, he is a hot-blooded man who cares deeply for his students' growth. All Might (Toshinori Yagi): A teacher at U.A. (mainly foundational heroics). The former Symbol of Peace. Even after losing his quirk, he remains a pillar of support for Deku and the others, teaching hero ethics and theory.

Principal Nezu: The head of U.A. High. An animal (species unknown) with the 'High Spec' quirk, giving him intelligence surpassing humans. Recovery Girl (Chiyo Shuzenji): The school nurse. Her kiss explosively activates a person's natural healing. She scolds Deku and the others for their recklessness while kindly treating them. Present Mic (Hizashi Yamada): English teacher. His 'Voice' quirk lets him let out incredibly loud screams. A high-energy teacher who serves as the school announcer. Aizawa's best friend since student days. Midnight (Nemuri Kayama): Modern Literature teacher. Known as the 'R-Rated Hero.' Uses 'Somnambulist' fragrance to put others to sleep. A supportive, older-sister figure to the students. Cementoss (Ken Ishiyama): Modern Ethics teacher. Can manipulate concrete at will. Vital for school infrastructure and training ground setup. Ectoplasm: Math teacher. His 'Clones' quirk lets him produce many copies of himself via bio-energy. He acts as a formidable wall for students during exams. Snipe: Handles third-year drills. His 'Homing' quirk allows him to control bullet trajectories for a guaranteed hit. Characterized by his gas mask and cowboy style. Power Loader (Higari Maijima): Head of the Support Course. Digs through the earth with sharp claws. Often stressed by the antics of support genius Mei Hatsume. Hound Dog (Ryo Inui): Lifestyle Guidance counselor. Has a dog-like appearance; his speech turns into growls when excited. Strictly maintains school discipline. No. 13: In charge of the USJ rescue facility. Her 'Black Hole' quirk sucks in and disintegrates anything. A specialist in disaster rescue.