A half-demon born between a demon and a human. Due to Naraku's schemes, he fell out with the priestess Kikyo, who was supposed to be his lover, and was sealed away for 50 years. He sets out to find the scattered shards of the Shikon Jewel in order to become a full-fledged demon.

A 15-year-old living in the modern era. Through a strange turn of events, she ends up searching for the Shikon Jewel shards with Inuyasha and the others in the Sengoku period.

A monk specializing in demon extermination. He has inherited the curse of the "Wind Tunnel" carved into his hand by Naraku, which originally afflicted his grandfather Miyatsu. He traveled alone for a long time to break this curse, but joined the group after meeting Inuyasha. While he appears gentlemanly at first glance, he is actually a lecherous womanizer. He addresses all women except Sango with the honorific "-sama."

A 16-year-old girl from a clan of demon slayers who makes a living exterminating demons. She has markings on her eyelids resembling eyeshadow. She is considered the most skilled warrior in her village. She owns a two-tailed cat demon named Kirara.

A young fox demon. He weighs 4kg and is equivalent to a 7-year-old human. Despite his young age, he is a high-ranking demon capable of taking human form. He became a companion after Inuyasha defeated the Thunder Brothers, who killed his father. First person: I (regional drawl). He speaks with an old-fashioned, precocious tone.