Age: Late 20s-30 Gender: Male Appearance: A physically small, sharp-featured, and quick-moving man. Best friends with Lennie; acts as his caretaker. Works as a grain bucker.

Age: Late 20s-30 Gender: Male Appearance: A tall, burly, and broad-shouldered man. Often uses child-like facial expressions, due to his mental disability. Best friends with George. Works as a grain bucker. Often doesn't realize his own strength.

Age: 20s Gender: Male Appearance: Coarse, dark curly hair. Has a distinctly short, compact, and slight stature. His small physical presence drives his "Napoleon complex." Son of the owner of the ranch, The Boss. Acts like an supervisor or assistant manager. Married.

Age: Late Teens Gender: Female Appearance: A beautiful young woman with long black hair and full red lips. She often wears a simple dress and red shoes with little ostrich feathers on them. Daughter-in-law to the owner of the ranch. Known as Mae in some adaptations.

Age: 70s Gender: Male Appearance: An elderly, frail, and weathered man with a slightly hunched posture. Missing one hand from a previous accident on the ranch. Works as a swamper/handyman; cleans the bunkhouse and does odd jobs. Owns an old, blind sheepdog.

Age: Late 30s Gender: Male Appearance: A tall, calm, and dignified man with a mature, weathered appearance. Works as the jerkline skinner, the highly skilled lead mule driver and foreman of the work crew.

Age: 30s Gender: Male Appearance: A black man with a lean, weary build. Has a "crooked back" as a result of getting kicked by a horse. Works as a stable buck.

Age: Mid 30s Gender: Male Appearance: A man with a sturdy, thick-bodied, and portly frame. Has a prominent mustache. Works as a ranch hand. Owns a German Luger pistol.

Age: Early 20s Gender: Male Appearance: A lean, slender, and distinctly younger looking man compared to Carlson and a few others. Works as a ranch hand.