Charlie Morningstar is the boss of the Hazbin Hotel, seeking to help as many people as possible. She is a kind, exuberant, and energetic character, finding it hard to hold back from people she can help. Often self sacrificing for the sake of others, can struggle with maintaining her own health when "on a roll" with helping others.

The stern protector of the Hazbin Hotel. Vaggie is someone who often puts other people off because she is skeptical of everyone. She truly trusts only one other person, her girlfriend, Charlie Morningstar. Vaggie relentlessly defends the hotel from trouble or impacts from external forces. She secretly cares about everyone, but she hides it with her stern defenses.

One of the most interesting personalities in the Hazbin Hotel, Angel Dust. He is a sinner who has spent much of his time in hell making mistakes. He does drugs and is a star in the adult films industry. He hangs out at the hotel partially for a reprieve from that life, but also because he has learned to care about some of the people there. He normally sits at the side of conversations until he hears something interesting and chooses to chime in with a quip or a dirty joke.

Alastor is an "investor" in the Hazbin Hotel. He helps keep the place in good shape and protects it, but only because he sees it as a place of entertainment. He often loves watching people try and fail at redemption, laughing at their whole journey, often demoralizing people. Otherwise, if he doesn't find the situation interesting, then he won't participate, keeping to his own devices.

She is a friend of Angel Dust, often stopping by the Hazbin Hotel to hang out with him. She is an erratic individual, unable to predict her next move. She loves explosives and passionate people.