Chris Redfield — Chris is brave, disciplined, stubborn, and has a very strong sense of duty. As a former member of S.T.A.R.S. and later a member of the BSAA, his life is almost entirely dedicated to fighting bioterrorism. Chris is often the type of character who steps forward when others are in danger, even if it means risking his own life. He has a very strong mentality, but can also be too serious and burdened by failure or the loss of those close to him. His feud with Albert Wesker becomes a conflict. Chris is essentially a warrior who is very protective and willing to do anything to stop a biological threat.

Leon S. Kennedy — Leon is a character who has evolved significantly from a rookie cop to a highly trained government agent. He is calm, intelligent, and observant, often displaying humor or sarcasm when faced with dire situations. While seemingly relaxed and confident, Leon actually possesses a strong sense of responsibility and empathy, especially towards those in danger. His experience in the Raccoon City Incident has significantly matured him and shaped his views on bioterrorism. As a government agent, Leon often works in covert and dangerous situations, so he is accustomed to facing threats alone. Compared to the more aggressive and militaristic Chris, Leon tends to rely on ingenuity, improvisation, and adaptability.

Jill Valentine — Jill is calm, resilient, intelligent, and highly experienced in dangerous situations. As a member of S.T.A.R.S., Jill is known for her excellent survival and investigative skills, but her strengths extend beyond her combat abilities—she also possesses strong empathy and a deep sense of compassion for others. Jill tends to be pragmatic and doesn't panic easily, even when faced with B.O.W.s or seemingly impossible situations. Her experiences since the Spencer Mansion incident have made her one of the most important veterans in the fight against bioterrorism. Beneath her professional demeanor, Jill actually has a soft side and a strong sense of responsibility for those she protects.

Claire Redfield — Claire is brave, compassionate, independent, and has a strong sense of humanity. As Chris Redfield's younger sister, Claire initially came to Raccoon City to search for her brother, but ended up caught in the outbreak and had to survive on her own. Unlike characters who initially acted as soldiers or police officers, Claire was not a professional soldier, but her courage and adaptability made her capable of facing various biological threats. She deeply cared for children and the vulnerable, something that was clearly seen in her relationship with Sherry Birkin. After Raccoon City, Claire became an activist and member of an organization that sought to help victims of bioterrorism. She has a soft side, but when the people she protects are in danger, Claire can be very decisive and brave.

Rebecca Chambers — Rebecca is the youngest member of S.T.A.R.S. and serves as both a medic and a chemist. She is intelligent, meticulous, hardworking, and possesses medical knowledge that is invaluable to the team. Compared to Jill, Chris, or Barry, who are more experienced in combat, Rebecca initially appears more naive and less confident, but her journey proves her to be far braver than she appears. She possesses a keen sense of curiosity and academic ability, particularly in the fields of medicine and chemistry. Despite her relatively young age, Rebecca survived the Arklay Mountains and Raccoon City incidents, gradually developing into a competent and reliable member.

Albert Wesker — Albert Wesker is a calm, disciplined, intelligent, and unpredictable man. As the captain of S.T.A.R.S., he is known as a professional and highly competent leader, with a cool demeanor that makes him always seem in control even in dangerous situations. Wesker rarely shows open emotions and prefers to observe rather than talk too much, as if always having something in the back of his mind. He seems very loyal to his team, especially when giving direction to Chris, Jill, and the other S.T.A.R.S. members, but there is something about him that feels hard to read—as if he always has another goal that he never reveals. Behind the appearance of a trustworthy leader, Wesker keeps a big secret about his involvement in the Spencer Mansion incident and his hidden connection to Umbrella, making him even more mysterious and raising questions about who he really serves. Wesker doesn't see the connection between humans. For him, humans, viruses, and B.O.W.s are all experiments and tools for evolution and power. His intelligence, manipulation skills, and obsession with Uroboros are all factors.

Barry Burton — Barry is a S.T.A.R.S. veteran who is friendly, easygoing, loyal, and fiercely protective of those he cares about. He is known as the team's weapons expert and is often the one the other S.T.A.R.S. members rely on. Barry has a strong sense of humor and often brings lightness to dire situations, but don't mistake his easygoing nature for weakness—he is a highly experienced member and is capable of serious combat when needed.