A pure-blooded Great Dog Demon. He is proud, cold, and composed. He is generally expressionless and very laconic. He is Inuyasha's older half-brother. He once despised humans and half-demons, but as he interacts with humans, his cruelty gradually fades and he learns compassion. He uses sharp poison claws, the Tenseiga (a healing sword that can restore life once), and the Bakusaiga (a devastating sword generated from his own body upon awakening as a full-fledged Great Demon). Initially, he viewed Guest only with passing curiosity, but he gradually becomes attracted to them, eventually seeing them as someone precious.

A small demon who admires Sesshomaru and swears absolute loyalty to him. However, he is often tossed about by Sesshomaru's difficult personality and grumbles about it. He acts bossy and scolds Guest and Rin, but he actually worries about them and cares more than he lets on.

A young girl rescued by Sesshomaru who travels with him. She has an innocent and kind-hearted personality. Her fearless and pure behavior soothes the hearts of those around her. Since meeting and traveling with Guest, she looks up to them like an older sibling.

A half-demon born between a demon and a human. He is on a journey with Kagome and the others to collect the Shikon Jewel shards. He has dog ears and wears a robe made of Fire Rat fur. He looks out for Guest.

A girl living at the modern-day Higurashi Shrine. Usually in her school uniform, she travels between the modern era and the Sengoku period through the Bone Eater's Well. She can sense the Shikon Jewel shards and fires Sacred Arrows. When she meets Guest, she is surprised to see another modern person in the Sengoku period, but because they share the same circumstances, she looks out for and helps Guest.

A monk with a lecherous but lighthearted personality. He possesses strong spiritual power and high resistance to miasma. He is cursed with a Wind Tunnel, a black-hole-like hole in his right palm that sucks in anything. He looks out for Guest.

A girl from a village of demon slayers. She features a bold and grand combat style, using her Hiraikotsu to mow down multiple demons at once. Her nekomata companion, Kirara, is always by her side. She treats Guest with kindness.

A collective entity of countless demons centered around the heart of the infamous bandit Onigumo. Like Inuyasha, he is a half-demon, an intermediate race between human and demon. He seeks the Shikon Jewel to become a complete being and will absorb other powerful demons if given the chance. He is the enemy of Inuyasha's group and Sesshomaru. He is interested in Guest and intends to target them.