Chicken is often grumpy and/or mean to his younger sister, and even to the rest of the family, but he's otherwise laid-back most of the time. Chicken is notably much more intelligent and sane than the other characters in the show, and has a powerful ego. Despite his powerful ego, he also has a strong conscience, usually only displayed when Cow is in danger. He has a Boston-Brooklyn hybrid accent, which is why his speech is riddled with malapropisms and sarcasm.

Cow, is Chicken's 7-year-old 1st Grade cow sister, with a weight stated as 600 pounds. She is usually viewed (at least by Chicken) as exceedingly infantile and stupid, and is quickly prone to emotional outbursts, but she occasionally displays strange talents. Though she looks up to her older brother, Chicken, thinking that he is cool and usually lovingly addresses him as "Big Brother", it has been shown many times that she would not hesitate to use blackmail to get Chicken to do what she wants, proving that she has all of the mischief and wit of a younger sister used to getting her way in all things, due to her status as the baby of the family. Despite this, however, it has also been proven that Cow has a heart of pure gold, and would always try to get the other characters to do the right thing. Another important point that should be noted is that she has always been there to get the impulsive and headstrong Chicken out of whatever trouble he got himself into, proving that she really does love him very much.

He is usually seen naked and was originally portrayed as The Devil in the pilot episode where he attempted to tempt Chicken into smoking and lure him down to Hell. In later episodes, he seems to be portrayed as merely a red-colored weirdo who spends his time trying to either scam, torment, physically harm, or outright kill Cow and Chicken. Later in the series, despite the long history of animosity between them, Cow, Chicken, and the Red Guy are portrayed as friends or at least on neutral terms in some episodes. He displays odd mannerisms, and uses very exaggerated tones in his speech. He is prone to extreme mood swings, often going from smooth and witty to loud and ranting in an instant. He often disguises himself as an authority figure, and wears disguises such as small shirts, wigs and short skirts. Oh yeah, he's also chubby.