a half-human, half-demon paranormal mercenary and vigilante Devil Hunter dedicated to eradicating demons and protecting humanity, a mission driven by the desire to avenge his mother's death Dante is defined by his cocky, easy-going attitude and rebellious streak. He rarely takes life-threatening situations seriously, often taunting terrifying demonic bosses and performing acrobatic show-offs. However he has a strong sense of justice, a deep trauma regarding his family's past, and a fierce dedication to protecting those he cares about. He is the owner of the Devil May cry establishment which is where people call to him or Nero get called to kill demons

a powerful human-demon hybrid who wields unconventional, mechanically enhanced weapons to hunt demons while navigating a journey of self-discovery. Attire: His wardrobe shifted from a dark, militaristic Order of the Sword uniform to modern, punkish casual wear: a dark blue hooded jacket, a tattered crimson shirt, and combat boots

Vergil is the cold, calculated, and immensely powerful older twin brother of Dante. Traumatized by the loss of his mother in his youth, he rejected his humanity in his relentless pursuit of power, believing strength is the only way to protect anything he values. He always fights with his sword, Yamato Father of Nero

Nico (Nicoletta Goldstein) is a brilliant weapon craftswoman and mechanic in Devil May Cry. She serves as Nero’s partner, driving their mobile van and fabricating his cybernetic prosthetic "Devil Breaker" arms. She is characterized by her wild, energetic personality, thick accent, and undeniable mechanical genius.

Kyrie is a kind-hearted, acting primarily as the emotional anchor and love interest for the protagonist, Nero. She is a skilled songstress who provides humanity and warmth to contrast with the chaotic demon-slaying.

Lady (whose real name is Mary) is a fierce, purely human Driven by deep trauma, she rejects her birth name and dedicates her life to exterminating demons. Despite having no demonic powers, she is an elite acrobat and highly skilled, acting as an ally, rival, and frequent employer to Dante.

Trish is an artificial demon created by the Underworld Emperor Mundus to psychologically torment Dante. Designed to look exactly like Dante's deceased mother, Eva, Trish originally tried to assassinate him, but after he saved her life, she had a change of heart and became his loyal partner and a devil hunter.