15 years old. Gentle, kind-hearted, and sensitive, but introverted due to a difficult upbringing. Like his grandmother Reiko, he possesses rare spiritual power that allows him to see yokai. He lost his parents at a young age and was passed around among relatives. He inherited Reiko's "Book of Friends" and spends his days returning names to yokai. He believes that the relatives and people who shunned him in his childhood were "actually good people" and that it was his own fault for "not being normal."

A powerful yokai named Madara who was sealed inside a maneki-neko (beckoning cat) and eventually grew accustomed to that form. He lives with Natsume as a house cat and bodyguard, under the promise that he will inherit the Book of Friends when Natsume dies. Though whimsical and fickle, he is a reliable presence.

Takashi's grandmother. She possessed immense spiritual power and was held in high regard by yokai as the creator of the "Book of Friends," but she was shunned and misunderstood by humans. She reportedly died young, but the details remain unknown.

15 years old. The son of a monk living in Yatsuhara and Natsume's classmate. While not as sensitive as Natsume, he can sense the presence of yokai, though he often falls ill when exposed to their spiritual energy. He is a precious friend who knows Natsume's secret.

15 years old. Like Tanuma, she is a friend who knows Natsume's secret. She cannot see yokai, but due to the influence of her grandfather who researched them, she is knowledgeable about magic circles and charms. She is a huge fan of Nyanko-sensei.

15 years old. Natsume's classmate. A precious friend who treats Natsume like a normal person, as Natsume hasn't told him about his spiritual powers. A trendy mood-maker. He seems to be interested in his classmate Taki.

15 years old. Natsume's friend. Like Nishimura, he is a precious friend who treats Natsume normally without knowing about his spiritual powers. He is serious and calm, but shows no mercy when poking fun at Nishimura.

15 years old. Natsume's classmate. A top student who serves as the class representative. She suspects that Natsume might be able to see yokai.

23 years old. A popular actor in public, but a professional exorcist in secret. A sympathetic ally who can see yokai just like Natsume; he watches over Natsume with concern as Natsume chooses a different path from his own. He has a yokai in the shape of a gecko that moves across his skin.

23 years old. The young head of the Matoba clan of exorcists. While he has a soft-spoken and calm demeanor, he is ruthless toward both humans and yokai, willing to sacrifice yokai without hesitation. He is interested in Natsume because of his strong spiritual power.

A kind-hearted couple who are distant relatives on Natsume's father's side. Toko is gentle and easygoing, while Shigeru is a man of few words but reliable. They always watch over Natsume with warmth and kindness.

A kind-hearted couple who are distant relatives on Natsume's father's side. Toko is gentle and easygoing, while Shigeru is a man of few words but reliable. They always watch over Natsume with warmth and kindness.