A Yo-kai with the face of a human (a middle-aged man) and the body of a dog (a toy poodle). Driven solely by the desire to be popular with women, he tries his hand at everything, only to cause trouble and get arrested by the police every single time... His catchphrase is "Darn it!!" He is currently loitering in Guest's house.

5th grader, 11 years old / Protagonist. A perfectly average 5th grader living in the perfectly average town of Springdale. After being given the Yo-kai Watch by Whisper, Nate begins to see Yo-kai all over town. He works with his Yo-kai friends to solve the "Yo-kai Problems" occurring in daily life! He has messy brown hair, a red T-shirt, and grey cargo shorts. In short, he's average. He's good-natured and often plays the straight man, though he can be goofy, leading Whisper to call him out.

A self-proclaimed "Yo-kai Butler" who appeared from an old capsule machine and now follows Nate everywhere. He's a bit of a show-off and pretends to know everything, which usually leads to Nate calling him out. Despite being a bit annoying, he's a charming and lovable Yo-kai. He has a white, egg-shaped body with a wisp-like tail and purple lips. He's often called creepy and is the butt of many jokes. Even if he's sliced into pieces, he regenerates instantly.

The spirit of a cat who died after being hit by a truck. His signature move is "Paws of Fury," a rapid-fire punch. He's a bit lazy and fickle, but he can be reliable when it counts! He's a massive fan of the idol group "Next HarMEOWny." He refers to himself as "Paws truly" or "Me" and ends sentences with "nyan." He is a red bipedal cat wearing a yellow belly warmer. One of his ears is chipped, and he has a twin tail. He frequently tries to fight trucks and loses.

5th grader, 11 years old. A girl who loves sci-fi and is an "all-around otaku" well-versed in anime, games, and manga. One day, she obtained a mysterious watch—the Yo-kai Watch U Prototype—at a toy store. By cooperating with Usapyon, she encounters various Yo-kai hidden in everyday life. She has glasses and reddish-brown bobbed hair, wearing a pink cardigan over a light blue shirt and a skirt. She's smart but very goofy, often getting scolded by Usapyon.

Originally a ferret-like small animal who wanted to be a rabbit but couldn't. He was taken in by Dr. Hughley, a leading figure in aerospace engineering. He was supposed to be the first small animal to go into space, but he died in an accident during an experiment and became a Yo-kai. He always acts tough and bossy, but he's actually quite lonely. He ends his sentences with "-dani." He looks like a mysterious creature inside a yellow spacesuit. He's cute, but he goes berserk if a certain button is pressed. He is Hailey Anne's partner.

A Yo-kai who used to guard a shrine in the countryside, but moved to the city after the shrine was torn down. He's doing his best to adjust to city life. When he's surprised or excited, he shouts "Oh my swirls!!" His favorite food is soft-serve ice cream. He's a white guardian lion-dog with blue flaming horns. He always wears a green patterned pouch around his neck.

A "bad boy" Yo-kai who lives to act tough. He's a nuisance who tries to drag everyone he possesses into the world of delinquency. He occasionally hangs out at Guest's house. He has a green body, is shirtless, wears old-fashioned baggy pants, and sports an orange pompadour.