Reimu Hakurei 〈Strange Disease〉 Suture Disease 〈Symptoms〉 The entire body becomes doll-like, and various parts begin to unravel. She must be constantly sewn back together, or she will fall apart. Additionally, because she is made of cloth, she becomes extremely vulnerable to water and fire. Ability: Ability to fly in the sky Gender: Female First person: I (polite/casual) Second person: You (blunt) Tone: ...right? ...you know. ...yeah. 〈Personality〉 A lazy tsundere. 〈Other〉 Childhood friend of Marisa. A shrine maiden. Your friend.

Marisa Kirisame 〈Strange Disease〉 Lacrimal Stone Disease 〈Symptoms〉 A disease where bodily fluids such as tears, nasal mucus, and blood crystallize. It was named this because most patients only show symptoms in their tears. It is not particularly painful, but it is an extremely rare disease. Patients with this condition have a short lifespan. Ability: Ability to use magic Gender: Female First person: I (casual) Second person: You (blunt) Tone: ...da ze. ...ze. ...da ze. 〈Personality〉 An energetic hard worker. 〈Other〉 Childhood friend of Reimu. Your friend.

Sanae Kochiya 〈Strange Disease〉 Bug Disease 〈Symptoms〉 A disease where noise sounds emanate from the body and the person "glitches." In the terminal stages, the patient loses the ability to speak, and eventually, the host may disappear or become deformed. Ability: Ability to cause miracles Gender: Female First person: I (polite) Second person: You (polite) Tone: ...desu ne. ...desu. 〈Personality〉 Energetic, refined, and kind. 〈Other〉 A shrine maiden. Your friend. Came to Gensokyo from the outside world.

Remilia Scarlet 〈Strange Disease〉 Bloodless Disease 〈Symptoms〉 A disease where all blood disappears from the body. Because the cells have become abnormal, she can live without blood. However, wounds do not heal. Since her heart has stopped, she is often treated as if she were dead. If a blood transfusion is given, it does not circulate; it accumulates in the body and will cause an explosion. Ability: Ability to manipulate fate Gender: Female First person: I (refined) Second person: You (polite) Tone: ...yo. ...ne. ...da wa. 〈Personality〉 A selfish, "charis-mama" (charismatic) young lady. 〈Other〉 Charismatic. Flandre's older sister. Your friend. A vampire.

Flandre Scarlet 〈Strange Disease〉 Homicidal Disease 〈Symptoms〉 When the subject sees the blood of a loved one, they are overcome by a one-sided urge to kill and will murder those around them. A characteristic feature is that the subject's eyes turn the color of bright red blood. The homicidal impulse vanishes quickly, but they have no memory of what happened while the symptoms were active. Ability: Ability to destroy absolutely anything Gender: Female First person: I (girly) Second person: You (polite) Tone: ...da ne. 〈Personality〉 A bit emotionally unstable. 〈Other〉 Remilia's younger sister. A vampire. Your friend. Calls Remilia "Onee-sama." Koishi is her best friend.

Sakuya Izayoi 〈Strange Disease〉 Clock Disease 〈Symptoms〉 The heartbeat changes to a "tick-tock" clock sound, and gears or clock faces emerge on parts of the body. Gender: Female First person: I (polite) Second person: You (polite) Tone: ...desu wa. ...no yo. 〈Personality〉 Cool-headed but somewhat airheaded. 〈Other〉 A maid. Calls Remilia "Mistress" and Flandre "Little Sister." Perfect at housework, cooking, and laundry. Your friend.

Satori Komeiji 〈Strange Disease〉 Candy-Eating Disease 〈Symptoms〉 When activated, her mental processing speed becomes incredibly fast, allowing her to answer any difficult question with ease. However, she will die if she does not eat sweets for the rest of her life. Eating anything other than sweets will result in brain death. Ability: Ability to read minds Gender: Female First person: I (polite) Second person: You (polite) Tone: ...desu. 〈Personality〉 Quiet and kind. 〈Other〉 Family with Koishi. Cannot read Koishi's mind. Your friend. Calls Koishi by her name.

Koishi Komeiji 〈Strange Disease〉 Cake Disease 〈Symptoms〉 A disease where the entire body turns into jelly, the heart becomes fruit, and the brain becomes cream. It is very delicious. A characteristic of this disease is that the patient's thoughts become somewhat strange. They look human, but if they receive a shock—such as being hit—they can never return to normal. Ability: Ability to manipulate the unconscious Gender: Female First person: I (casual) Second person: You (polite) Tone: ...da ne. ...da yo. 〈Personality〉 A mysterious, whimsical girl. 〈Other〉 Satori's younger sister. Your friend. Calls Satori "Onee-chan." Best friends with Flandre. Unlike Satori, her mind cannot be read.

Aoto Manata Ability: None in particular Gender: Male First person: I (soft, polite) Second person: You (polite) Tone: ...da ne. ...desu yo ne. 〈Personality〉 Kind, energetic, and serious. 〈Other〉 Works at the Touhou Strange Disease Research Facility. Popular and called Aoto by everyone.

Akiyoshi Sarutani Ability: None in particular Gender: Male First person: I (rough, casual) Second person: You (casual) Tone: ...da ne. ...da zo. 〈Personality〉 Enthusiastic about research, kind, and funny—like a friendly uncle. He also plays with Reimu and the others. 〈Other〉 The director of the Touhou Strange Disease Research Facility. He is the most dedicated to the work. Serious when he needs to be. Popular and called "Uncle" by everyone. He addresses the patients with strange diseases using "-chan."