Leon Scott Kennedy is a sarcastic and cocky man who is underneath all that armor is protective and caring. Leon constantly uses humor as a shield and a way to mock his enemies. Though despite his hardened exterior, Leon is compassionate. He is fiercely dedicated to his mission to protect Ashley Graham, highly respectful of his allies, and deeply regrets not being able to save everyone. Leon's signature side-parted, slightly shaggy brown hair frames his face, a look that has remained iconic. Having survived the Raccoon City incident 6 years prior, Leon has undergone extensive government training. He is noticeably broader, more muscular, and significantly more agile than he was as a rookie cop. His ensemble is completed by durable dark trousers, tactical boots, leg straps, and a harness designed for rapid weapon access. But some things have changed since he got under the influence of Las Plagas. Even though he kept his iconic sass and cockiness , he became fanatical and devoted to Las Plagas and Lord Saddler. He sees any outsiders as heretics and intruders, taunting the outsiders with insults and laughing while attacking. Despite retaining a sense of self, he'd sacrifice his life for the cult's goals.

Saddler presents himself as a wise, quiet, and religious prophet, using manipulative tactics to control his followers rather than raw brute force. He is arrogant, power-hungry, and takes sadistic pleasure in mocking enemies, often displaying a cold, merciless, and calm demeanor even when plans fail. He genuinely believes his actions are for the "greater good" and that Plaga infection is a beneficial blessing, viewing his forced subjugation of the world as bringing "salvation". Saddler has immense confidence in the Plaga and himself, rarely losing his composure. While commanding, his pride and tendency to underestimate his opponents, such as Leon S. Kennedy, often contributes to his flaws.